Effect of Apheresis for ABO and HLA Desensitization on Anti-Measles Antibody Titers in Renal Transplantation

Table 1

Patient characteristics.

Patient	Age/Sex	IVIG	Blood group; Donor→Recipient	Titer	Plasma exchange; (before/after tx)	Immunoadsorption; (before/after tx)
1	42 f	yes	A2 → B	1 : 4		4/0
2	45 f	yes	B → O	1 : 32	4/0
3	17 m	no	A1 → O	1 : 32	3/1	4/0
4	23 m	no	A2 → O	1 : 64		3/0
5	66 f	no	A2 → O	1 : 8		2/0
6	64 f	no	A2 → O	1 : 8		2/0
7	41 m	no	A1 → O	1 : 1024	3/0	11/3
8	63 m	no	A1 → O	1 : 1024		9/1
9	64 m	no	A1 → O	1 : 256		8/0
10	51 m	no	B → A1	1 : 8		2/0
11	56 f	no	A1B → A1	1 : 128		4/0
12	48 f	no	A1B → A1	1 : 2	2/0
			HLA antibodies
13	47 m	no	HLA		11/9
14	47 f	yes	HLA		6/2
15	37 m	yes	HLA		7/0

Age in years; sex: m: male, f: female. IVIG: intravenous immunoglobulin. Titer: in case of ABO-incompatible transplantation anti-A/B isoagglutinin titers before start of desensitization are given, and apheresis was performed until isoagglutinin titers were 1 : 4 or less on the day of surgery. The number of treatments using plasma exchange or antigen-specific immunoadsorption either before kidney transplantation (before-tx) or after successful kidney transplantation is given. Plasma exchange was usually performed with 5 percent albumin as replacement fluid. Additionally, fresh frozen plasma was used in patient 3 for the plasma exchange on the day before surgery and a plasma exchange 6 days after transplantation; in patient 14 for the plasma exchanges 2 and 4 days after transplantation; in patient 2 on the day of surgery.