β-Cell Generation: Can Rodent Studies Be Translated to Humans?

Table 1

Potential sources of de novo β-cells among differentiated adult cell types.

	Rodent		Human
	in vitro	in vivo	in vitro	in vivo
Endocrine
β -cells	+++	+++	−	−/+
α-cells	?	++	?	?
Exocrine
Ductal cells	++	+	+	++
Acinar cells	+	−/+	?	?
Extra-pancreatic
Liver cells	?	++	+	?