Table of Contents Author Guidelines Submit a Manuscript
Journal of Transplantation
Volume 2011, Article ID 948740, 6 pages
http://dx.doi.org/10.1155/2011/948740
Research Article

Xenotransplantation of Human Neural Progenitor Cells to the Subretinal Space of Nonimmunosuppressed Pigs

1Department of Ophthalmology, University Hospital of Lund, 22185 Lund, Sweden
2Children’s Hospital of Orange County, Orange, CA 92868-3874, USA
3Eye Deptartment and Eye Pathology Institution, Rigshospitalet, 2100 Copenhagen, Denmark
4Copenhagen Ophthalmology Center, Glostrup Hospital, 2600 Copenhagen, Denmark
5Harvard Medical School, Schepens Eye Research Institute, Boston, MA 02114, USA
6Stem Cell Research Center, Sue and Bill Gross Hall, University of California, Room 2035, 845 Health Sciences Road, Irvine, CA 92697-1705, USA

Received 2 January 2011; Accepted 12 April 2011

Academic Editor: Waldo Concepcion

Copyright © 2011 Karin Warfvinge et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. Klassen and B. Reubinoff, “Stem cells in a new light,” Nature Biotechnology, vol. 26, no. 2, pp. 187–188, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. D. A. Lamba, J. Gust, and T. A. Reh, “Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice,” Cell Stem Cell, vol. 4, no. 1, pp. 73–79, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. Y. Hirami, F. Osakada, K. Takahashi et al., “Generation of retinal cells from mouse and human induced pluripotent stem cells,” Neuroscience Letters, vol. 458, no. 3, pp. 126–131, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. M. J. Young, J. Ray, S. J. Whiteley, H. Klassen, and F. H. Gage, “Neuronal differentiation and morphological integration of hippocampal progenitor cells transplanted to the retina of immature and mature dystrophic rats,” Molecular and Cellular Neurosciences, vol. 16, no. 3, pp. 197–205, 2000. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. H. J. Klassen, T. F. Ng, Y. Kurimoto et al., “Multipotent retinal progenitors express developmental markers, differentiate into retinal neurons, and preserve light-mediated behavior,” Investigative Ophthalmology and Visual Science, vol. 45, no. 11, pp. 4167–4173, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  6. R. E. MacLaren, R. A. Pearson, A. MacNeil et al., “Retinal repair by transplantation of photoreceptor precursors,” Nature, vol. 444, no. 7116, pp. 203–207, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. A. Otani, K. Kinder, K. Ewalt, F. J. Otero, P. Schimmel, and M. Friedlander, “Bone marrow-derived stem cells target retinal astrocytes and can promote or inhibit retinal angiogenesis,” Nature Medicine, vol. 8, no. 9, pp. 1004–1010, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  8. H. Klassen, B. Ziaeian, I. I. Kirov, M. J. Young, and P. H. Schwartz, “Isolation of retinal progenitor cells from post-mortem human tissue and comparison with autologous brain progenitors,” Journal of Neuroscience Research, vol. 77, no. 3, pp. 334–343, 2004. View at Google Scholar · View at Scopus
  9. H. Mizumoto, K. Mizumoto, S. J. Whiteley, M. Shatos, H. Klassen, and M. J. Young, “Transplantation of human neural progenitor cells to the vitreous cavity of the Royal College of Surgeons rat,” Cell Transplant, vol. 10, no. 2, pp. 223–233, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. H. Mizumoto, K. Mizumoto, M. A. Shatos, H. Klassen, and M. J. Young, “Retinal transplantation of neural progenitor cells derived from the brain of GFP transgenic mice,” Vision Research, vol. 43, no. 16, pp. 1699–1708, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. S. J. Van Hoffelen, M. J. Young, M. A. Shatos, and D. S. Sakaguchi, “Incorporation of murine brain progenitor cells into the developing mammalian retina,” Investigative Ophthalmology and Visual Science, vol. 44, no. 1, pp. 426–434, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  12. K. Warfvinge, J. F. Kiilgaard, E. B. Lavik et al., “Retinal progenitor cell xenografts to the pig retina: morphologic integration and cytochemical differentiation,” Archives of Ophthalmology, vol. 123, no. 10, pp. 1385–1393, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. K. Warfvinge, J. F. Kiilgaard, H. Klassen et al., “Retinal progenitor cell xenografts to the pig retina: immunological reactions,” Cell Transplant, vol. 15, no. 7, pp. 603–612, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. H. Klassen, J. F. Kiilgaard, T. Zahir et al., “Progenitor cells from the porcine neural retina express photoreceptor markers after transplantation to the subretinal space of allorecipients,” Stem Cells, vol. 25, no. 5, pp. 1222–1230, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. H. Klassen, P. H. Schwartz, B. Ziaeian et al., “Neural precursors isolated from the developing cat brain show retinal integration following transplantation to the retina of the dystrophic cat,” Veterinary Opthalmology, vol. 10, no. 4, pp. 245–253, 2007. View at Google Scholar · View at Scopus
  16. P. J. Francis, S. Wang, Y. Zhang et al., “Subretinal transplantation of forebrain progenitor cells in nonhuman primates: survival and intact retinal function,” Investigative Ophthalmology and Visual Science, vol. 50, no. 7, pp. 3425–2431, 2009. View at Google Scholar · View at Scopus
  17. J. Hori, T. F. Ng, M. Shatos, H. Klassen, J. W. Streilein, and M. J. Young, “Neural progenitor cells lack immunogenicity and resist destruction as allografts,” Stem Cells, vol. 21, no. 4, pp. 405–416, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. H. Klassen, K. L. Imfeld, J. Ray, M. J. Young, F. H. Gage, and M. A. Berman, “The immunological properties of adult hippocampal progenitor cells,” Vision Research, vol. 43, no. 8, pp. 947–956, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. C. N. Svendsen, M. G. Ter Borg, R. J. Armstrong et al., “A new method for the rapid and long term growth of human neural precursor cells,” Journal of Neuroscience Methods, vol. 85, no. 2, pp. 141–152, 1998. View at Publisher · View at Google Scholar · View at Scopus
  20. P. H. Schwartz, P. J. Bryant, T. J. Fuja, H. Su, D. K. O'Dowd, and H. Klassen, “Isolation and characterization of neural progenitor cells from post-mortem human cortex,” Journal of Neuroscience Research, vol. 74, no. 6, pp. 838–851, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  21. U. Aftab, C. Jiang, B. Tucker et al., “Growth kinetics and transplantation of human retinal progenitor cells,” Experimental Eye Research, vol. 89, no. 3, pp. 301–310, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. C. Jiang, H. Klassen, X. Zhang, and M. Young, “Laser injury promotes migration and integration of retinal progenitor cells into host retina,” Molecular Vision, vol. 16, pp. 983–990, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus