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Journal of Transplantation
Volume 2011, Article ID 970421, 11 pages
http://dx.doi.org/10.1155/2011/970421
Review Article

ABO Incompatible Kidney Transplantation—Current Status and Uncertainties

Division of Transplant Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, No. 50 Ilwon-dong, Kangnam-ku, Seoul 135-710, Republic of Korea

Received 14 June 2011; Accepted 23 October 2011

Academic Editor: Eric Thervet

Copyright © 2011 Milljae Shin and Sung-Joo Kim. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. W. D. Park, J. P. Grande, D. Ninova et al., “Accommodation in ABO-incompatible kidney allografts, a novel mechanism of self-protection against antibody-mediated injury,” American Journal of Transplantation, vol. 3, no. 8, pp. 952–960, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. C. J. Sonnenday, D. S. Warren, M. Cooper et al., “Plasmapheresis, CMV hyperimmune globulin, and anti-CD20 allow ABO-incompatible renal transplantation without splenectomy,” American Journal of Transplantation, vol. 4, no. 8, pp. 1315–1322, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. A. A. R. Tobian, R. S. Shirey, R. A. Montgomery et al., “ABO antibody titer and risk of antibody-mediated rejection in ABO-incompatible renal transplantation,” American Journal of Transplantation, vol. 10, no. 5, pp. 1247–1253, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. A. A. R. Tobian, R. S. Shirey, R. A. Montgomery, P. M. Ness, and K. E. King, “The critical role of plasmapheresis in ABO-incompatible renal transplantation,” Transfusion, vol. 48, no. 11, pp. 2453–2460, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. C. C. Magee, “Transplantation across previously incompatible immunological barriers,” Transplant International, vol. 19, no. 2, pp. 87–97, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. B. H. Chung, J. Y. Lee, S. H. Kang et al., “Comparison of clinical outcome between high and low baseline anti-ABO antibody titers in ABO-incompatible kidney transplantation,” Renal Failure, vol. 33, no. 2, pp. 150–158, 2011. View at Publisher · View at Google Scholar
  7. D. J. Cook, B. Graver, and P. I. Terasaki, “ABO incompatibility in cadaver donor kidney allografts,” Transplantation Proceedings, vol. 19, no. 6, pp. 4549–4552, 1987. View at Google Scholar · View at Scopus
  8. N. P. Couch, R. E. Wilson, E. B. Hager, and J. E. Murray, “Transplantation of cadaver kidneys: experience with 21 cases,” Surgery, vol. 59, no. 2, pp. 183–188, 1966. View at Google Scholar · View at Scopus
  9. G. Dunea, S. Nakamoto, R. A. Straffon et al., “Renal homotransplantation in 24 patients,” British Medical Journal, vol. 1, no. 5426, pp. 7–13, 1965. View at Google Scholar · View at Scopus
  10. T. E. Starzl, T. L. Marchioro, J. H. Holmes et al., “Renal homografts in patients with major donor-recipient blood group incompatibilities,” Surgery, vol. 55, no. 2, pp. 195–200, 1964. View at Google Scholar · View at Scopus
  11. J. Thielke, B. Kaplan, and E. Benedetti, “The role of ABO-incompatible living donors in kidney transplantation: state of the art,” Seminars in Nephrology, vol. 27, no. 4, pp. 408–413, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. H. Genberg, G. Kumlien, L. Wennberg, and G. Tydén, “Isoagglutinin adsorption in ABO-incompatible transplantation,” Transfusion and Apheresis Science, vol. 43, no. 2, pp. 231–235, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. H. Ishida, K. Tanabe, H. Toma, and T. Akiba, “Therapeutic apheresis therapy for ABO-incompatible renal transplantations,” Therapeutic Apheresis, vol. 7, no. 6, pp. 520–528, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. G. Tydén, G. Kumlien, H. Genberg, J. Sandberg, T. Lundgren, and I. Fehrman, “ABO incompatible kidney transplantations without splenectomy, using antigen-specific immunoadsorption and rituximab,” American Journal of Transplantation, vol. 5, no. 1, pp. 145–148, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. R. A. Montgomery, “Renal transplantation across HLA and ABO antibody barriers: integrating paired donation into desensitization protocols,” American Journal of Transplantation, vol. 10, no. 3, pp. 449–457, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. T. Oettl, J. Halter, A. Bachmann et al., “ABO blood group-incompatible living donor kidney transplantation: a prospective, single-centre analysis including serial protocol biopsies,” Nephrology Dialysis Transplantation, vol. 24, no. 1, pp. 298–303, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. H. Genberg, G. Kumlien, L. Wennberg, U. Berg, and G. Tydén, “ABO-incompatible kidney transplantation using antigen-specific immunoadsorption and rituximab: a 3-year follow-up,” Transplantation, vol. 85, no. 12, pp. 1745–1754, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. G. Tydén, J. Donauer, J. Wadström et al., “Implementation of a protocol for ABO-incompatible kidney transplantation—a three-center experience with 60 consecutive transplantations,” Transplantation, vol. 83, no. 9, pp. 1153–1155, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. J. M. Gloor and M. D. Stegall, “ABO incompatible kidney transplantation,” Current Opinion in Nephrology and Hypertension, vol. 16, no. 6, pp. 529–534, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. K. Tanabe, “Japanese experience of ABO-incompatible living kidney transplantation,” Transplantation, vol. 84, supplement 12, pp. S4–S7, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Fuchinoue, Y. Ishii, T. Sawada et al., “The 5-year outcome of ABO-incompatible kidney transplantation with rituximab induction,” Transplantation, vol. 91, no. 8, pp. 853–857, 2011. View at Publisher · View at Google Scholar
  22. M. E. Fidler, J. M. Gloor, D. J. Lager et al., “Histologic findings of antibody-mediated rejection in ABO blood-group-incompatible living-donor kidney transplantation,” American Journal of Transplantation, vol. 4, no. 1, pp. 101–107, 2004. View at Publisher · View at Google Scholar · View at Scopus
  23. G. Tydén, G. Kumlien, and M. Efvergren, “Present techniques for antibody removal,” Transplantation, vol. 84, supplement 12, pp. S27–S29, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. R. J. Crew and L. E. Ratner, “ABO-incompatible kidney transplantation: current practice and the decade ahead,” Current Opinion in Organ Transplantation, vol. 15, no. 4, pp. 526–530, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. J. M. Gloor, D. J. Lager, M. E. Fidler et al., “A comparison of splenectomy versus intensive posttransplant antidonor blood group antibody monitoring without splenectomy in ABO-incompatible kidney transplantation,” Transplantation, vol. 80, no. 11, pp. 1572–1577, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. K. Takahashi, “Recent findings in ABO-incompatible kidney transplantation: classification and therapeutic strategy for acute antibody-mediated rejection due to ABO-blood-group-related antigens during the critical period preceding the establishment of accommodation,” Clinical and Experimental Nephrology, vol. 11, no. 2, pp. 128–141, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. T. Becker, M. Samaniego-Picota, and H. W. Sollinger, “The emerging role of rituximab in organ transplantation,” Transplant International, vol. 19, no. 8, pp. 621–628, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. D. L. Segev, C. E. Simpkins, D. S. Warren et al., “ABO incompatible high-titer renal transplantation without splenectomy or anti-CD20 treatment,” American Journal of Transplantation, vol. 5, no. 10, pp. 2570–2575, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. D. Toki, H. Ishida, S. Horita, K. Setoguchi, Y. Yamaguchi, and K. Tanabe, “Impact of low-dose rituximab on splenic B cells in ABO-incompatible renal transplant recipients,” Transplant International, vol. 22, no. 4, pp. 447–454, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. S. M. Flint, R. G. Walker, C. Hogan et al., “Successful ABO-incompatible kidney transplantation with antibody removal and standard immunosuppression,” American Journal of Transplantation, vol. 11, no. 5, pp. 1016–1024, 2011. View at Publisher · View at Google Scholar
  31. R. A. Montgomery, J. E. Locke, K. E. King et al., “ABO incompatible renal transplantation: a paradigm ready for broad implementation,” Transplantation, vol. 87, no. 8, pp. 1246–1255, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. H. Ogawa, M. M. Mohiuddin, D. P. Yin, J. Shen, A. S. Chong, and U. Galili, “Mouse-heart grafts expressing an incompatible carbohydrate antigen. II. Transition from accommodation to tolerance,” Transplantation, vol. 77, no. 3, pp. 366–373, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. H. Ishida, K. Tanabe, T. Ishizuka et al., “The mechanism responsible for accommodation after living-related kidney transplantations across the blood barrier,” Transplant International, vol. 18, no. 6, pp. 716–720, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. L. J. West, “Targeting antibody-mediated rejection in the setting of ABO-incompatible infant heart transplantation: Graft accommodation vs. B cell tolerance,” Current Drug Targets—Cardiovascular and Haematological Disorders, vol. 5, no. 3, pp. 223–232, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. A. D. Griesemer, M. Okumi, A. Shimizu et al., “Upregulation of CD59: potential mechanism of accommodation in a large animal model,” Transplantation, vol. 87, no. 9, pp. 1308–1317, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. M. M. Mohiuddin, H. Ogawa, D. P. Yin, J. Shen, and U. Galili, “Antibody-mediated accommodation of heart grafts expressing an incompatible carbohydrate antigen,” Transplantation, vol. 75, no. 3, pp. 258–262, 2003. View at Publisher · View at Google Scholar · View at Scopus
  37. R. N. Smith, T. Kawai, S. Boskovic et al., “Four stages and lack of stable accommodation in chronic alloantibody-mediated renal allograft rejection in cynomolgus monkeys,” American Journal of Transplantation, vol. 8, no. 8, pp. 1662–1672, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. A. D. Kirk, W. M. Baldwin, M. I. Cascalho, A. S. Chong, M. Sykes, and L. J. West, “American Society of Transplantation symposium on B cells in transplantation: harnessing humoral immunity from rodent models to clinical practice,” American Journal of Transplantation, vol. 7, no. 6, pp. 1464–1470, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. A. T. Chang and J. L. Platt, “The role of antibodies in transplantation,” Transplantation Reviews, vol. 23, no. 4, pp. 191–198, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. A. Delikouras and A. Dorling, “Transplant accommodation,” American Journal of Transplantation, vol. 3, no. 8, pp. 917–918, 2003. View at Publisher · View at Google Scholar · View at Scopus
  41. A. D. Salama, A. Delikouras, C. D. Pusey et al., “Transplant accommodation in highly sensitized patients: a potential role for Bcl-xL and alloantibody,” American Journal of Transplantation, vol. 1, no. 3, pp. 260–269, 2001. View at Publisher · View at Google Scholar · View at Scopus
  42. M. D. Stegall, P. G. Dean, and J. M. Gloor, “ABO-incompatible kidney transplantation,” Transplantation, vol. 78, no. 5, pp. 635–640, 2004. View at Google Scholar
  43. R. Higgins, D. Lowe, M. Hathaway et al., “Double filtration plasmapheresis in antibody-incompatible kidney transplantation,” Therapeutic Apheresis and Dialysis, vol. 14, no. 4, pp. 392–399, 2010. View at Publisher · View at Google Scholar · View at Scopus
  44. M. Geyer, J. Donauer, P. Pisarski et al., “Preemptive postoperative antigen-specific immunoadsorption in ABO-incompatible kidney transplantation: necessary or not?” Transplantation, vol. 84, supplement 12, pp. S40–S43, 2007. View at Publisher · View at Google Scholar · View at Scopus
  45. L. K. Kayler, J. L. Farber, B. Colombe, D. LaCava, J. J. Friedewald, and L. E. Ratner, “Characterization of rejection episodes in patients following positive crossmatch and ABO-incompatible live donor renal transplantation,” Transplant International, vol. 19, no. 2, pp. 128–139, 2006. View at Publisher · View at Google Scholar · View at Scopus
  46. K. Takahashi, “Accommodation in ABO-incompatible kidney transplantation: why do kidney grafts survive?” Transplantation Proceedings, vol. 36, no. 2, supplement, pp. 193S–196S, 2004. View at Publisher · View at Google Scholar · View at Scopus
  47. K. Takahashi, “A new concept of accomodation in ABO-incompatible kidney transplantation,” Clinical Transplantation, vol. 19, supplement 14, pp. 76–85, 2005. View at Google Scholar · View at Scopus
  48. J. Wilpert, K. G. Fischer, P. Pisarski et al., “Long-term outcome of ABO-incompatible living donor kidney transplantation based on antigen-specific desensitization. An observational comparative analysis,” Nephrology, Dialysis, Transplantation, vol. 25, no. 11, pp. 3778–3786, 2010. View at Google Scholar
  49. D. Toki, H. Ishida, S. Horita, Y. Yamaguchi, and K. Tanabe, “Blood group O recipients associated with early graft deterioration in living ABO-incompatible kidney transplantation,” Transplantation, vol. 88, no. 10, pp. 1186–1193, 2009. View at Publisher · View at Google Scholar · View at Scopus
  50. D. Toki, H. Ishida, K. Setoguchi et al., “Acute antibody-mediated rejection in living ABO-incompatible kidney transplantation: long-term impact and risk factors,” American Journal of Transplantation, vol. 9, no. 3, pp. 567–577, 2009. View at Publisher · View at Google Scholar · View at Scopus
  51. H. Ushigome, M. Okamoto, K. Koshino et al., “Findings of graft biopsy specimens within 90 days after ABO blood group incompatible living donor kidney transplantation compared with ABO-identical and non-identical transplantation,” Clinical Transplantation, vol. 24, supplement 22, pp. 16–21, 2010. View at Publisher · View at Google Scholar · View at Scopus
  52. L. C. Racusen and M. Haas, “Antibody-mediated rejection in renal allografts: lessons from pathology,” Clinical Journal of the American Society of Nephrology, vol. 1, no. 3, pp. 415–420, 2006. View at Publisher · View at Google Scholar · View at Scopus
  53. K. Setoguchi, H. Ishida, H. Shimmura et al., “Analysis of renal transplant protocol biopsies in ABO-incompatible kidney transplantation,” American Journal of Transplantation, vol. 8, no. 1, pp. 86–94, 2008. View at Publisher · View at Google Scholar · View at Scopus
  54. M. Haas, M. H. Rahman, L. C. Racusen et al., “C4d and C3d staining in biopsies of ABO- and HLA-Incompatible renal allografts: correlation with histologic findings,” American Journal of Transplantation, vol. 6, no. 8, pp. 1829–1840, 2006. View at Publisher · View at Google Scholar · View at Scopus
  55. M. Haas, D. L. Segev, L. C. Racusen et al., “C4d deposition without rejection correlates with reduced early scarring in ABO-incompatible renal allografts,” Journal of the American Society of Nephrology, vol. 20, no. 1, pp. 197–204, 2009. View at Publisher · View at Google Scholar · View at Scopus
  56. S. A. Just, N. Marcussen, U. Sprogøe, P. Koefoed-Nielsen, and C. Bistrup, “Acute antibody-mediated rejection after ABO-incompatible kidney transplantation treated successfully with antigen-specific immunoadsorption,” Nephrology Dialysis Transplantation, vol. 25, no. 1, pp. 310–313, 2010. View at Publisher · View at Google Scholar · View at Scopus
  57. J. P. Venetz and M. Pascual, “New treatments for acute humoral rejection of kidney allografts,” Expert Opinion on Investigational Drugs, vol. 16, no. 5, pp. 625–633, 2007. View at Publisher · View at Google Scholar · View at Scopus
  58. J. Galliford, R. Charif, K. K. Chan et al., “ABO incompatible living renal transplantation with a steroid sparing protocol,” Transplantation, vol. 86, no. 7, pp. 901–906, 2008. View at Publisher · View at Google Scholar · View at Scopus
  59. R. A. Montgomery, A. A. Zachary, L. C. Racusen et al., “Plasmapheresis and intravenous immune globulin provides effective rescue therapy for refractory humoral rejection and allows kidneys to be successfully transplanted into cross-match-positive recipients,” Transplantation, vol. 70, no. 6, pp. 887–895, 2000. View at Google Scholar · View at Scopus
  60. B. Kaplan, A. Gangemi, J. Thielke, J. Oberholzer, H. Sankary, and E. Benedetti, “Successful rescue of refractory, severe antibody mediated rejection with splenectomy,” Transplantation, vol. 83, no. 1, pp. 99–100, 2007. View at Publisher · View at Google Scholar · View at Scopus
  61. J. J. Everly, R. C. Walsh, R. R. Alloway, and E. S. Woodle, “Proteasome inhibition for antibody-mediated rejection,” Current Opinion in Organ Transplantation, vol. 14, no. 6, pp. 662–666, 2009. View at Publisher · View at Google Scholar · View at Scopus
  62. J. P. Chuang, C. J. Hung, S. S. Chang, T. C. Chou, and P. C. Lee, “Does immunosuppressive pharmacotherapy affect isoagglutinin titers?” Transplantation Proceedings, vol. 40, no. 8, pp. 2685–2687, 2008. View at Publisher · View at Google Scholar · View at Scopus