Journal of Transplantation

Clinical Study

Estimation of Abbreviated Cyclosporine A Area under the Concentration-Time Curve in Allogenic Stem Cell Transplantation after Oral Administration

Table 3

Correlations and regression equations between AUC0–12 h and CsA concentration at each time point.
Sampling time (h)Model equation for
abbreviated AUC (μg·h/mL)		Pearson 𝑅 2
0 A U C 0 - 1 2 h = 1 . 5 9 + 1 3 . 3 7 1 × 𝐶 0 0.391
0.5 A U C 0 - 1 2 h = 2 . 7 7 9 + 3 . 1 9 7 × 𝐶 0 . 5 0.481
1 A U C 0 - 1 2 h = 3 . 3 3 2 + 1 . 5 5 8 × 𝐶 1 0.596
1.5 A U C 0 - 1 2 h = 1 . 7 9 7 + 3 . 6 3 9 × 𝐶 1 . 5 0.712
2 A U C 0 - 1 2 h = 1 . 3 8 4 + 4 . 2 6 8 × 𝐶 2 0.848
3 A U C 0 - 1 2 h = 1 . 5 2 + 4 . 7 6 × 𝐶 3 0.835
4 A U C 0 - 1 2 h = 1 . 8 1 8 + 5 . 3 5 7 × 𝐶 4 0.897
6 A U C 0 - 1 2 h = 1 . 4 7 9 + 9 . 6 5 1 × 𝐶 6 0.660
8 A U C 0 - 1 2 h = 1 . 3 7 + 1 2 . 6 8 3 × 𝐶 8 0.717
12 A U C 0 - 1 2 h = 1 . 7 7 2 + 1 4 . 4 8 9 × 𝐶 1 2 0.786
𝐶 𝑥 concentration at 𝑥 time, AUC area under the concentration-time curve.