c-Jun-N-Terminal Kinase Signaling Is Involved in Cyclosporine-Induced Epithelial Phenotypic Changes

<table>Cyclosporine (CsA) activates JNK signaling. (a) Representative western blot of JNK and p-JNK expression in primary cultures of HRECs exposed to the vehicle or 6 <i>μ</i>M CsA for various incubation times. (b) Real-time PCR analysis of EGR1 mRNA expression in cells that were exposed to 6 <i>μ</i>M CsA with or without the 2 <i>μ</i>M JNK inhibitor (L)-JNKI1.</table>

Journal of Transplantation

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Figure 1

Figure 1: c-Jun-N-Terminal Kinase Signaling Is Involved in Cyclosporine-Induced Epithelial Phenotypic Changes 