c-Jun-N-Terminal Kinase Signaling Is Involved in Cyclosporine-Induced Epithelial Phenotypic Changes
Cyclosporine induces Snail-1 expression in a JNK-dependent manner. (a) Representative western blot of Snail-1 expression in tubular cells during exposure for various incubation times with 6 μM CsA or 6 μM CsA + (L)-JNKI1. (b) Densitometric analysis of Snail-1 expression in three independent experiments. * versus control. (c) Real-time PCR analysis of Snail-1 mRNA expression in tubular cells that were exposed for various incubation times with 6 μM CsA with or without 2 μM (L)-JNKI1.