The Hepatoprotective Effect of Sodium Nitrite on Cold Ischemia-Reperfusion Injury

Figure 8

Nitrite-supplemented solutions mitigated reductions in Bcl-2 concentrations. Bcl-2 protein (pooled from 3 livers per condition) expression decreased during cold preservation with both LR (18 hours) and UW solutions (48 hours) alone but significantly increased when the respective solutions were supplemented with 250 μM of anion nitrite (LR—5.9±0.6 versus LR + nitrite—8.8±1; UW—4.4±1.3 versus UW + nitrite—10.8±1.1). Supplemented UW solution demonstrated the greatest increase in protein expression. Data are expressed as mean ± SE. ^#𝑃<0.05 for corresponding measurements.

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