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Journal of Transplantation
Volume 2012, Article ID 842141, 7 pages
Review Article

The Major Histocompatibility Complex in Transplantation

1Investigación, Hospital Regional de Alta Especialidad del Bajío, Blvd. Milenio No. 130, San Carlos/La Roncha, 37660 León, GTO, Mexico
2HGSZ No.10 del Instituto Mexicano del Seguro Social Delegación Guanajuato, Cantador No. 17, 36000, GTO, Mexico
3Departamento de Medicina y Nutrición,Universidad de Guanajuato, 20 de Enero No. 929, 37000 León, GTO, Mexico

Received 15 January 2012; Revised 12 April 2012; Accepted 19 April 2012

Academic Editor: Niels Olsen Saraiva Camara

Copyright © 2012 Marco Antonio Ayala García et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The transplant of organs is one of the greatest therapeutic achievements of the twentieth century. In organ transplantation, the adaptive immunity is considered the main response exerted to the transplanted tissue, since the principal target of the immune response is the MHC (major histocompatibility complex) molecules expressed on the surface of donor cells. However, we should not forget that the innate and adaptive immunities are closely interrelated and should be viewed as complementary and cooperating. When a human transplant is performed, HLA (human leukocyte antigens) molecules from a donor are recognized by the recipient's immune system triggering an alloimmune response Matching of donor and recipient for MHC antigens has been shown to have a significant positive effect on graft acceptance. This paper will present MHC, the innate and adaptive immunities, and clinical HLA testing.