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Journal of Transplantation
Volume 2012, Article ID 872894, 5 pages
Clinical Study

Creatinine-Based Estimations of Kidney Function Are Unreliable in Obese Kidney Donors

Department of Medicine, University of Illinois at Chicago, 820 S. Wood Street, M/C 793, Chicago, IL 60612-7315, USA

Received 1 September 2011; Accepted 7 November 2011

Academic Editor: R. Michael Hofmann

Copyright © 2012 Nidhi Aggarwal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Accurate assessment of kidney function by measurement of glomerular filtration rate (GFR) is essential to the risk assessment of prospective living kidney donors. We evaluated the performance of various estimating equations for creatinine clearance (Cockcroft-Gault), GFR (Modification of Diet in Renal Disease, Chronic Kidney Disease Epidemiology Collaboration), and 24-hour urine collections for creatinine clearance in obese potential kidney donors. We evaluated 164 potential kidney donors including 49 with a BMI of 30–35 and 32 with a BMI >35 that have completed a routine living donor evaluation with a measured GFR. All the estimating equations performed poorly in obese donors. While 24-hour urine collections performed better, only 15% had an adequate 24-hour urine collection. Since obese kidney donors may be at higher than average risk for kidney failure, accurate assessment of kidney function in these donors is crucial to ensure their long-term health postdonation.