New Onset Diabetes Mellitus in Living Donor versus Deceased Donor Liver Transplant Recipients: Analysis of the UNOS/OPTN Database

Table 4

Independent risk factors for development of NODAT for all DDLT recipients (𝑛=19, 582).

Variable		Univariate; HR (95% CI)	𝑃 value	Multivariate; HR (95% CI)	𝑃 value
Recipient age	>50 versus ≤50	1.27 (1.20–1.35)	<0.0001	1.14 (1.06–1.22)	0.0003
Recipient gender	Male versus female	1.16 (1.10–1.23)	<0.0001	1.13 (1.06–1.21)	0.0002
Recipient race	AA versus others	1.20 (1.03–1.39)	0.0019	1.09 (0.93–1.28)	0.2994
	Caucasian versus others	1.05 (0.93–1.20)	0.4128	0.95 (0.83–1.09)	0.4842
	Hispanic versus others	1.17 (1.01–1.35)	0.033	1.05 (0.90–1.22)	0.540
Recipient BMI	>30 versus ≤25	1.32 (1.23–1.42)	<0.0001	1.26 (1.16–1.35)	<0.0001
	25–30 versus ≤25	1.17 (1.10–1.26)	<0.0001	1.14 (1.06–1.23)	0.0004
Donor age	≥60 versus <60	1.26 (1.18–1.35)	<0.0001	1.21 (1.12–1.30)	<0.0001
Etiology of liver disease	ALD versus others	1.26 (1.14–1.39)	<0.0001	1.22 (1.10–1.36)	0.0002
	HCV versus others	1.37 (1.28–1.48)	<0.0001	1.34 (1.24–1.46)	<0.0001
	NASH + cryptogenic cirrhosis versus others	1.53 (1.37–1.70)	<0.0001	1.45 (1.29–1.63)	<0.0001
Rejection	Treated rejection versus no rejection	3.31 (3.02–3.62)	<0.0001	3.51 (3.20–3.84)	<0.0001
Donor history of diabetes	Yes versus no	1.18 (1.08–1.30)	0.0002	1.20 (1.10–1.31)	0.0001

DDLT: deceased donor liver transplant; AA: African American; BMI: body mass index; ALD: alcohol liver disease; HCV: hepatitis C virus; NASH: nonalcoholic steatohepatitis; HR: hazard ratio; CI: confidence interval.