|
| ILMN Gene ID no. | Genes | P | FC | Known cellular function (Ref.) | Role in HCC (Ref.) | HCC-R secondary to HCV (Ref.) |
|
| 1667213 | DNA fragmentation factor, 45 kDa, alpha polypeptide (DFFA) | 0.0011 | 5.24 | (1) Tumor suppressor gene [22].
(2) Protein encoded by DFFA gene known as inhibitor of caspase-activated DNase (ICAD), involved in DNA fragmentation during apoptosis [23]. | Unknown | Unknown |
|
| 1664111 | Ring finger and FYVE-like domain containing E3 ubiquitin protein ligase (RFFL) | 0.0005 | 4.72 | (1) RFFL is a member of caspase 8/10-associated RING proteins (CARPs) are a recently described family of protein ubiquitin ligases that interact with and negatively regulate death receptor-mediated apoptosis [24]. | Unknown | Unknown |
|
| 1675626 | PRP38 pre-mRNA processing factor 38 (yeast) domain containing (PRPF38A) | 0.0005 | 4.28 | (1) PRP38 pre-mRNA processing factor 38 (yeast) domain containing A protein involved in pre-mRNA splicing [25]. | Unknown | Unknown |
|
| 1767747 | Histone deacetylase 2 (HDAC2) | | 4.05 | (1) This gene product belongs to the histone deacetylase family known to play an important role in transcriptional regulation, cell cycle progression and developmental events.
(2) Role in antiapoptosis in tumor cells [26]. | [27] | Unknown |
|
| 2147863 | Glutamine and serine rich 1 (QSER1) | | 3.98 | Unknown | Unknown | [28] |
|
| 2354211 | Regulator of chromosome condensation 1 (RCC1) | 0.0002 | 5.32 | (1) Regulator of chromosomal condensation [29]. | Unknown | Unknown |
|
| 2404135 | RIO kinase 3 (yeast) (RIOK3) | <0.0001 | 5.00 | (1) The specific function of this gene has not yet been determined (NCBI).
(2) Recent study identified Rio kinase 3 (RIOK3) as an amplified gene that alters cytoskeletal architecture as well as promotes pancreatic ductal cell migration and invasion [30]. | Unknown | |
|
| 1770822 | Ribosomal protein S6 kinase, 90 kDa, polypeptide 3 (RPS6KA3) | 0.0001 | 4.77 | (1) Known to regulating cell growth and differentiation [31].
(2) Known to play a role in the cellular antiviral response [32]. | [33] | Unknown |
|
| 1663195 | Minichromosome maintenance complex component 7 (MCM7) | 0.0031 | 4.78 | (1) Respective protein involved in regulating DNA replication [34].
(2) MCM7 overexpression and amplification and several human malignancies [35]. | [36] | Unknown |
|
| 1801928 | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide (YWHAZ) | 0.0007 | 5.18 | (1) The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity [37].
(2) Known to promote malignancies in many cell types [38]. | [39] | Unknown |
|
| 2057981 | Zinc finger, C2HC-type containing 1A (FAM164A) | 0.0008 | 4.90 | Unknown | Unknown | Unknown |
|
| 1782551 | E2F transcription factor 5, p130-binding (E2F5) | <0.0001 | 6.60 | (1) A transcription factor regulates cell proliferation and differentiation [40].
(2) Over-expressed in several human malignancies [41]. | [37] | Unknown
|
|
| 3307266 | PSMC3 interacting protein (PSMC3IP) | 0.0006 | 5.23 | (1) This gene encodes a protein that functions in meiotic recombination [42]. | Unknown | Unknown |
|
| 2131936 | ATPase family, AAA domain containing 3B (ATAD3B) | 0.001 | 4.55 | (1) ATAD3B is mitochondrial membrane proteins that contribute to the stabilization of large mitochondrial DNA (mtDNA) protein complexes called nucleoids [43]. | Unknown | Unknown |
|
| 1683660 | Eukaryotic translation initiation factor 3, subunit H (EIF3H) | 0.0016 | 4.27 | (1) At the cellular level, EIF3H overexpression increases proliferation, growth and survival [44].
(2) Inhibit induction of apoptosis [44]. | [45] | Unknown |
|
| 3309468 | Hypothetical protein MGC12982 (MGC12982) | 0.0006 | 4.09 | Unknown | Unknown | Unknown |
|
| 1697363 | Chromosome 20 open reading frame 27 (C20ORF27) | 0.0003 | 4.15 | Unknown | Unknown | Unknown |
|
