Significance of Urinary Proteome Pattern in Renal Allograft Recipients

Table 1

Classification of urinary proteomes based on their molecular weight characteristics.

	Urinary proteome	Molecular weight (Da)	Sources	Examples	Graft abnormalities
1	Smaller molecular weight	1000 to 20,000	Inflammatory and interstitial cell product.	Interleukins, granzyme, perforin, and so forth.	AR, ATN, UTI, CNI toxicity, CAAR, and IFTA.
2	Low molecular weight	10,000 to 33,000	Tubular overflow.	Alpha-1 μ-globulin, Beta-2 μ-globulin, RBP, and so forth.	Physiological, UTI, and ATN.
3	Middle and high molecular weight	60,000 to 150,000	Glomerular leak.	Albumin, transferrin, and immuno-globulins.	GN, TG, and mTOR induced.

Da: Dalton, AR: acute rejection, ATN: acute tubular necrosis, UTI: urinary tract infection, CNI: calcineurin inhibitor, CAAR: chronic-antibody-associated-rejection with C4d deposits, IFTA: interstitial-nephritis-tubular-atrophy, RBP: retinol binding protein, GN: glomerulonephritis, TG: transplant glomerulopathy, and mTOR: mammalian target of rapamycin.