| | | Graft dysfunction | Nature of proteomes | Sources | Urinary proteome patterns
(molecular weight (Da)) |
| | 1 | Normal native kidney | Spill over proteomes. | Renal cells. | Peak at 9754.
Increased frequency at 1668, 1817, 1687, 1782, 1882, and 2154. |
| | 2 | Normal renal allograft | Beta-2 μ-globulin, human defensin, and so forth. | Passenger cells and spill over proteomes. | Enhancement at 3370, 3441, 3385, 4303, 4309, 4449, 5090, 4139, 5627, 5563, 5459, 10350, and 11732 (beta-2 μ-globulin). |
| | 3 | Acute graft rejection | Adhesion molecules, cytokines, perforin, granzyme, and activation of complement cascade and coagulation cascade peptides and their degradation products. | APC, B and T-lymphocytes, NK cells, macrophages, and so forth. | Enhancement at 2003, 2807, 4756, 5872, 6990, and 19018, 25665. |
| | 4 | Acute tubular necrosis | NGAL, KIM-1, and NaHE-3. | Tubular epithelial cells. | Enhancement at 5500–7500 range and at 6400, 28500, 33000, 4300, and 66000. |
| | 5 | UTI | | | 2327, 5065, 3485, 16356, 4825, and 6647. |
| | 6 | CNI toxicity |
Downregulation of extracellular matrix/cell adhesion components and the
upregulation of secreted cyclophilin A and cyclophilin B, macrophage inhibition
factor and phosphatidyl-ethanolamine-binding protein-1, and so forth. |
| | 7 | CAAR | Clusters in MS regions, which are not seen in healthy urine protein profile. | EMT cells and Lymphocytes. | 2628 to 2922, 4307 to 4799, and 8303 to 8850. |
| | 8 | IFTA | | EMT cells and Fibroblasts. | Significant underexpressed features in the range of 2850 to 3050 from that of CAAR. |
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Da: Dalton, CNI: calcineurin inhibitor, CAAR: chronic antibody associated rejection with C4d deposits, IFTA: interstitial nephritis tubular atrophy NGAL: neutrophil-gelatinase-associated-ligand, KIM-1: kidney-injury-molecule-1, NaHE-3: sodium-transporter-at-apical-membrane, APC: antigen-presenting cell, MS: mass spectrometry, and EMT: epithelial-to-mesenchymal transformation.
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