An Association between BK Virus Replication in Bone Marrow and Cytopenia in Kidney-Transplant Recipients
Table 3
Biological parameters of patients with BKV replication within bone marrow.
Patient number
Time to cytopenia (months)
Hemoglobin level (g/dL)
PMN count (/mm3)
Platelet count (/mm3)
Lymphocyte count (/mm3)
CD4-positive cell count (/mm3)
CD8-positive cell count (/mm3)
CD19-positive cell count (/mm3)
Gamma globulins (g/dL)
eGFR* (mL/min)
Viruses in bone marrow (/mL)
Viruses in blood (/mL)
1
4.5
12.9
713
231,000
700
575
297
58
6.2
54
BKV (3.24)
None
2
20
11.8
800
93,000
373
125
220
35
4.8
19
BKV (3.01)
BKV (3)
3
25
16.5
990
140,000
450
365
390
51
7.8
21
BKV (3.01)-EBV
EBV
4
12
9.4
678
187,000
155
34
27
13
4.5
17
BKV (3.2)
BKV (2.8)
5
12
13.1
430
249,000
500
280
223
100
5.7
19
BKV (3.02)
BKV (5)
6
15
10.7
100
65,000
1000
884
790
0
5
12
BKV (2.74)
BKV (2.8)
7
46.5
10.8
50
115,000
730
—
—
0
6
15
BKV (2.94)
None
8
6.5
13.5
726
99,000
700
297
174
91
—
32
BKV (3.1)
BKV (2.8)
The glomerular filtration rate was calculated using the Modification of the Diet in Renal Disease (MDRD) equation. PMN: polymorphonuclear leukocytes; eGFR: estimated glomerular-filtration rate.
