Peak Serum AST Is a Better Predictor of Acute Liver Graft Injury after Liver Transplantation When Adjusted for Donor/Recipient BSA Size Mismatch (ASTi)
Figure 2
Prediction of PNF by AST and ASTi. Receiver-operating-characteristic (ROC) curves for AST and adjusted AST (ASTi) at risk for primary nonfunction of graft (PNF) show the relationship between true positive and false positive rates for a test across various threshold values used to diagnose a condition. The area under the curve (C statistic) for the ROC shown in ASTi is 0.930. The C statistic for AST in the same cohort was 0.900. ASTi is better predicting posttransplant PNF. UNOS criteria of PNF had sensitivity of 75% and specificity of 97.7% in our cohort of study population. Combination of ASTi ≥3,500 IU/L and PT-INR ≥2.3 had the best predictive value of sensitivity 87.5% and specificity of 98.0%, which is better than UNOS criteria.
