Review Article

The Role of mTOR Inhibitors in Liver Transplantation: Reviewing the Evidence

Table 6

The effects of sirolimus in liver transplant recipients with concomitant hepatocellular carcinoma.

Overall survival rate at 1 year after transplant (%)Overall survival rate at 2 years after transplant (%)Overall survival rate at 3 years after transplant (%)Overall survival rate at 4 years after transplant (%)Overall survival rate at 5 years after transplant (%)Mortality risk ratio (SRL : CNI)

Maintenance dosing
Toso et al. Hepatology. 2010; 51: 1237–43 [65]85.6 versus 79.2 (SRL versus SRL-free)83.1 versus 68.7 (SRL versus SRL-free, )
Kneteman et al. Liver Transpl. 2004; 10: 1301–11 [63]94.1 (Milan criteria) 90.5 (extended criteria)81.1 (Milan criteria), 76.8 (extended criteria)

De novo dosing
Chinnakotla et al. Liver Transpl. 2009; 15: 1834–42 [55]94 versus 79 (SRL versus TAC)85 versus 66 (SRL versus TAC)80 versus 59 (SRL versus TAC, )
Zhou et al. Transplant Proc. 2008; 40: 3548–53 [59]90.67 versus 61.60 (SRL versus TAC, )80.59 versus 53.90 (SRL versus TAC, )
Zimmerman et al. Liver Transpl. 2008; 14: 633–8 [15]95.5 versus 83 (SRL versus CNI)78.8 versus 62 (SRL versus CNI)0.672

Late conversion (>3 months after transplantation)
Vivarelli et al. Transplant Proc. 2010; 42: 2579–84 [80]84

values are included where available.
CNI: calcineurin inhibitor; NS: nonsignificant; SRL: sirolimus; TAC: tacrolimus.