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Journal of Transplantation
Volume 2015, Article ID 163757, 9 pages
http://dx.doi.org/10.1155/2015/163757
Research Article

Delayed Graft Function in Kidney Transplants: Time Evolution, Role of Acute Rejection, Risk Factors, and Impact on Patient and Graft Outcome

1Department of Nephrology, Dialysis and Transplantation and Department of Abdominal Surgery, CUB, Erasmus Hospital, Route de Lennik 808, 1070 Brussels, Belgium
2Research Center of Biostatistics, Epidemiology and Clinical Research, School of Public Health, Route de Lennik 808, 1070 Brussels, Belgium
3Nephrology Department, Antwerp University Hospital, Free University of Brussels, Wilrijkstraat 10, 2650 Edegem, Belgium

Received 29 April 2015; Accepted 26 August 2015

Academic Editor: F. H. J. Claas

Copyright © 2015 Martin Chaumont et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. G. Yarlagadda, S. G. Coca, A. X. Garg et al., “Marked variation in the definition and diagnosis of delayed graft function: a systematic review,” Nephrology Dialysis Transplantation, vol. 23, no. 9, pp. 2995–3003, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Siedlecki, W. Irish, and D. C. Brennan, “Delayed graft function in the kidney transplant,” American Journal of Transplantation, vol. 11, no. 11, pp. 2279–2296, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. W. D. Irish, J. N. Ilsley, M. A. Schnitzler, S. Feng, and D. C. Brennan, “A risk prediction model for delayed graft function in the current era of deceased donor renal transplantation,” American Journal of Transplantation, vol. 10, no. 10, pp. 2279–2286, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. S. K. Akkina, J. J. Connaire, A. K. Israni, J. J. Snyder, A. J. Matas, and B. L. Kasiske, “Similar outcomes with different rates of delayed graft function may reflect center practice, not center performance,” American Journal of Transplantation, vol. 9, no. 6, pp. 1460–1466, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. P. F. Halloran, “Immunosuppressive drugs for kidney transplantation,” The New England Journal of Medicine, vol. 351, no. 26, pp. 2715–2729, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. A. S. Klein, E. E. Messersmith, L. E. Ratner, R. Kochik, P. K. Baliga, and A. O. Ojo, “Organ donation and utilization in the United States, 1999–2008: special feature,” American Journal of Transplantation, vol. 10, no. 4, pp. 973–986, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Sharif and R. Borrows, “Delayed graft function after kidney transplantation: the clinical perspective,” American Journal of Kidney Diseases, vol. 62, no. 1, pp. 150–158, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. W. D. Irish, D. A. McCollum, R. J. Tesi et al., “Nomogram for predicting the likelihood of delayed graft function in adult cadaveric renal transplant recipients,” Journal of the American Society of Nephrology, vol. 14, no. 11, pp. 2967–2974, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. C. Ponticelli, “Ischaemia-reperfusion injury: a major protagonist in kidney transplantation,” Nephrology Dialysis Transplantation, vol. 29, no. 6, pp. 1134–1140, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. H. I. Feldman, R. Gayner, J. A. Berlin et al., “Delayed function reduces renal allograft survival independent of acute rejection,” Nephrology Dialysis Transplantation, vol. 11, no. 7, pp. 1306–1313, 1996. View at Publisher · View at Google Scholar · View at Scopus
  11. D. A. Shoskes and J. M. Cecka, “Deleterious effects of delayed graft function in cadaveric renal transplant recipients independent of acute rejection,” Transplantation, vol. 66, no. 12, pp. 1697–1701, 1998. View at Publisher · View at Google Scholar · View at Scopus
  12. F. Moreso, D. Serón, S. Gil-Vernet et al., “Donor age and delayed graft function as predictors of renal allograft survival in rejection-free patients,” Nephrology Dialysis Transplantation, vol. 14, no. 4, pp. 930–935, 1999. View at Publisher · View at Google Scholar · View at Scopus
  13. C. Troppmann, K. J. Gillingham, E. Benedetti et al., “Delayed graft function, acute rejection, and outcome after cadaver renal transplantation: a multivariate analysis,” Transplantation, vol. 59, no. 7, pp. 962–968, 1995. View at Publisher · View at Google Scholar · View at Scopus
  14. D. Mikhalski, K. M. Wissing, L. Ghisdal et al., “Cold ischemia is a major determinant of acute rejection and renal graft survival in the modern era of immunosuppression,” Transplantation, vol. 85, no. 7S, pp. S3–S9, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. S. G. Yarlagadda, S. G. Coca, R. N. Formica, E. D. Poggio, and C. R. Parikh, “Association between delayed graft function and allograft and patient survival: a systematic review and meta-analysis,” Nephrology Dialysis Transplantation, vol. 24, no. 3, pp. 1039–1047, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Sharif, S. Shabir, S. Chand, P. Cockwell, S. Ball, and R. Borrows, “Meta-analysis of calcineurin-inhibitor-sparing regimens in kidney transplantation,” Journal of the American Society of Nephrology, vol. 22, no. 11, pp. 2107–2118, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. M. G. J. Snoeijs, B. Wiermans, M. H. Christiaans et al., “Recipient hemodynamics during non-heart-beating donor kidney transplantation are major predictors of primary nonfunction,” American Journal of Transplantation, vol. 7, no. 5, pp. 1158–1166, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Chapal, F. Le Borgne, C. Legendre et al., “A useful scoring system for the prediction and management of delayed graft function following kidney transplantation from cadaveric donors,” Kidney International, vol. 86, pp. 1130–1139, 2014. View at Publisher · View at Google Scholar · View at Scopus
  19. C. Jeldres, H. Cardinal, A. Duclos et al., “Prediction of delayed graft function after renal transplantation,” Journal of the Canadian Urological Association, vol. 3, no. 5, pp. 377–382, 2009. View at Google Scholar · View at Scopus
  20. P. Vereerstraeten, “Préparation du receveur de greffe rénale,” in Transplantation d'organes et greffe de tissus, P. Hervé, Ed., pp. 690–701, Editions Inserm, Paris, France, 1994. View at Google Scholar
  21. P. Vereerstraeten, D. Abramowicz, L. De Pauw, and P. Kinnaert, “Absence of deleterious effect on long-term kidney survival of rejection episodes with complete functional recovery,” Transplantation, vol. 63, pp. 1739–1743, 1997. View at Google Scholar
  22. A. Rahmel, Ed., Annual Report 2013, Eurotransplant International Foundation, Leiden, The Netherlands, 2013.
  23. Abacus Concepts, Survival Tools for Stat-View, Abacus Concepts, Berkeley, Calif, USA, 1994.
  24. S. R. Knight, N. K. Russell, L. Barcena, and P. J. Morris, “Mycophenolate mofetil decreases acute rejection and may improve graft survival in renal transplant recipients when compared with azathioprine: a systematic review,” Transplantation, vol. 87, no. 6, pp. 785–794, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. “KDIGO clinical practice guideline for the care of kidney transplant recipients. Chapter 1: induction therapy,” American Journal of Transplantation, vol. 9, supplement 3, pp. S6–S9, 2009.
  26. T. Wujciak and G. Opelz, “A proposal for improved cadaver kidney allocation,” Transplantation, vol. 56, no. 6, pp. 1513–1517, 1993. View at Publisher · View at Google Scholar · View at Scopus
  27. U.S. Renal Data System, USRDS 2013 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Md, USA, 2013.
  28. M. Carlier, J. P. Squifflet, Y. Pirson, L. Decocq, B. Gribomont, and G. P. Alexandre, “Confirmation of the crucial role of the recipient's maximal hydration on early diuresis of the human cadaver renal allograft,” Transplantation, vol. 36, no. 4, pp. 455–456, 1983. View at Publisher · View at Google Scholar · View at Scopus
  29. P. Schnuelle and F. J. van der Woude, “Perioperative fluid management in renal transplantation: a narrative review of the literature,” Transplant International, vol. 19, no. 12, pp. 947–959, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Y.-M. Wang and K.-N. Lai, “The importance of residual renal function in dialysis patients,” Kidney International, vol. 69, no. 10, pp. 1726–1732, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Ishikawa, S. M. Flechner, D. A. Goldfarb et al., “Quantitative assessment of the first acute rejection as a predictor of renal transplant outcome,” Transplantation, vol. 68, no. 9, pp. 1318–1324, 1999. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Humar, A. Hassoun, R. Kandaswamy, W. D. Payne, D. E. R. Sutherland, and A. J. Matas, “Immunologic factors: the major risk for decreased long-term renal allograft survival,” Transplantation, vol. 68, no. 12, pp. 1842–1846, 1999. View at Publisher · View at Google Scholar · View at Scopus
  33. F. Qureshi, H. Rabb, and B. L. Kasiske, “Silent acute rejection during prolonged delayed graft function reduces kidney allograft survival,” Transplantation, vol. 74, no. 10, pp. 1400–1404, 2002. View at Publisher · View at Google Scholar · View at Scopus
  34. N. M. Butala, P. P. Reese, M. D. Doshi, and C. R. Parikh, “Is delayed graft function causally associated with long-term outcomes after kidney transplantation? Instrumental variable analysis,” Transplantation, vol. 95, no. 8, pp. 1008–1014, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. G. Tripepi, G. Heinze, K. J. Jager, V. S. Stel, F. W. Dekker, and C. Zoccali, “Risk prediction models,” Nephrology Dialysis Transplantation, vol. 28, no. 8, pp. 1975–1980, 2013. View at Publisher · View at Google Scholar · View at Scopus