Journal of Transplantation

Review Article

MicroRNAs in Kidney Transplantation: Living up to Their Expectations?

Table 1

Up- and downregulated miRNAs found in in vivo studies. miRNA−: downregulated miRNA, miRNA+: upregulated miRNA, MV: microvesicles, EPC: endothelial progenitor cells, and AmiR = antagomir.


Author	Species	Focus	Control	Tissue	Time point	MicroRNA−	MicroRNA+

Wei et al. [16], 2010	Mice	Dicer−/− in proximal tubules 30 min renal IRI	Wild type	Cortex	12 h	miR-18 miR-127 miR-135b miR-296 miR-322 miR-379 miR-487b miR-491	miR-17-3p miR-132 miR-207 miR-362 miR-489 miR-685 miR-687
Wei et al. [16], 2010	Mice	Dicer−/− in proximal tubules 30 min renal IRI	Wild type	Cortex	48 h	miR-324-3p miR-379 miR-455-3p	miR-7 miR-132 miR-362 miR-467 miR-486 miR-495 miR-668 miR-694

Godwin et al. [17], 2010	Mice	30 min renal IRI	Sham	Kidney	1-3-5-7-14-21-30 days	miR-187 miR-192 miR-194 miR-805	miR-20a miR-21 miR-146a miR-199a-3p miR-214

Xu et al. [19], 2012	Mice	15 min preconditioning before 30 min renal IRI	IRI/IRI + anti-miR-21	Kidney	4 h 24 h 4 days		miR-21

Jia et al. [28], 2013	Mice	Xenon preconditioning before 30 min renal IRI	IRI/IRI + anti-miR-21	Kidney	24 h		miR-21

Kaucsár et al. [24], 2013	Mice	20 and 30 min IRI	Sham	Kidney	24 h 3 days 4 days		miR-17-5 miR-21 miR-106

Saikumar et al. [18], 2012	Rat	30 min renal IRI	Sham	Kidney cortex	24 h		miR-21 miR-155 miR-18a

Cantaluppi et al. [20], 2012	Rat	MV EPC + 45 min renal IRI	Sham IRI IRI MV EPC (+RNAse/siRNA/AmiR126/296) IRI MV fibroblast	Kidney	2 days 7 days 180 days		miR-126 miR-296