Lung Transplantation in Patients with High Lung Allocation Scores in the US: Evidence for the Need to Evaluate Score Specific Outcomes

Table 1

Characteristics of patients at baseline, stratified by quartiles of LAS.

Recipient-related	Quartile 1	Quartile 2	Quartile 3	Quartile 4	value
	(26.3–34.5)	(34.6–39.3)	(39.4–48.6)	(48.7–95.7)
	Age, years (SD)	57.3 (10.0)	53.3 (13.9)	53.8 (13.8)		54.6 (13.5)	<0.001
Male, (%)	1,357 (52.7)	1,521 (59.1)	1,602 (62.2)	1,581 (61.4)	<0.001
White, (%)	2,340 (90.8)	2,198 (85.3)	2,076 (80.6)	2,025 (78.6)	<0.001
Body mass index, Kg/m^2 (SD)	25.2 (4.3)	24.5 (4.8)	25.2 (4.7)	25.2 (4.8)
Diabetes, (%)	240 (9.3)	450 (17.5)	527 (20.6)	608 (23.6)	<0.001
Diagnosis
Idiopathic pulmonary fibrosis	153 (5.9)	741 (28.8)	1,297 (50.3)	1,531 (59.4)	<0.001
COPD/emphysema	1,800 (69.8)	760 (29.5)	185 (7.2)	100 (3.9)
Cystic fibrosis	106 (3.3)	439 (17.0)	404 (15.7)	307 (11.9)
Pulmonary hypertension	86 (16.7)	75 (2.9)	90 (3.5)	44 (1.7)
Other	431 (16.7)	561 (21.8)	600 (23.3)	594 (23.1)
Mechanical ventilator, (%)	58 (2.3)	70 (2.7)	71 (2.8)	382 (14.8)	<0.001
ECMO support (%)	4 (0.2)	7 (0.3)	7 (0.3)	111 (4.3)	<0.001
GFR
GFR <60	212 (8.2)	194 (7.5)	188 (7.3)	201 (7.8)	<0.001
60–90	965 (37.5)	911 (35.4)	894 (34.7)	747 (29.0)
>90	1,399 (54.3)	1,471 (57.1)	1,494 (58.0)	1,628 (63.2)
Chronic steroid use, (%)	976 (37.9)	1,140 (44.3)	1,273 (49.4)	1,436 (55.8)	<0.001
Donor-related
Age, years (SD)	34.6 (14.3)	33.9 (14.3)	33.8 (14.1)	34.4 (14.2)	0.13
Transplant related
Admission to ICU, (%)	52 (2.0)	68 (2.6)	86 (3.3)	566 (22.0)	<0.001
Graft ischemic time, hours (SD)	4.8 (1.7)	5.0 (1.6)	5.2 (1.7)	5.3 (1.7)	<0.001
Waiting time, days (IQR)	104 (33–310)	97 (29–269)	64 (22–205)	36 (10–130)	<0.001
Bilateral transplant (%)	1,581 (61.4)	1,679 (65.2)	1,662 (65.5)	1,833 (71.2)	<0.001

LAS: lung allocation score, : number, SD: standard deviation, BMI: body mass index, COPD: chronic obstructive pulmonary disease, ECMO: extracorporeal membrane oxygenation, GFR: glomerular filtration rate, and ICU: intensive care unit.