Everolimus and Malignancy after Solid Organ Transplantation: A Clinical Update

Table 2

Case reports of conversion to everolimus for nonmelanoma skin cancer after solid organ transplantation.

	Age (years)/type of tx	Type (number) of NMSC	Time post-tx to switch to everolimus, months	Original IS regimen	Everolimus-based IS regimen	Other intervention for NMSC	Follow-up (months)	Outcome for NMSC
Fernández et al. 2006 [51]	70/kidney	SCC (3)	89	CsA	Everolimus	None	Mean 6.5 months	Existing lesions improved; No recurrence
Fernández et al. 2006 [51]	69/kidney	SCC (1), BCC (1)	65	Tacrolimus	Everolimus	Excision	Mean 6.5 months	No recurrence
Fernández et al. 2006 [51]	64/kidney	SCC (6)	116	CsA; MMF	Everolimus; MMF	None	Mean 6.5 months	Existing lesions resolved; No recurrence
Fernández et al. 2006 [51]	70/kidney	SCC (17), BCC (1)	206	Tacrolimus	Everolimus	Excision	Mean 6.5 months	No recurrence
Fernández et al. 2006 [51]	67/kidney	SCC (1), BCC (2)	130	CsA; MMF	Everolimus; MMF	None	Mean 6.5 months	Existing lesions resolved; No recurrence
Fernández et al. 2006 [51]	69/kidney	SCC (2), BCC (1) & actinic keratosis (1)	178	CsA	Everolimus	Excision	Mean 6.5 months	No recurrence
Pascual et al. 2006 [66]	64/kidney	Recurrent cutaneous neoplasms (5)	Not stated	CsA; MMF; Steroids	Everolimus; MMF; Steroids	Excision	9	No recurrence
Alter et al. 2014 [67]	71/kidney	SCC (4), BD (2)	36	CsA; MMF; Steroids	Everolimus; MMF; Steroids	Excision, curettage, and photodynamic therapy	24 months	SCC (2)
Alter et al. 2014 [67]	49/heart	BCC (2), BD (1)	180	CsA; AZA; Steroids	Everolimus; CsA	Excision, curettage, and photodynamic therapy	24 months	BCC (2)
Alter et al. 2014 [67]	44/lung	SCC (3), BD (3)	264	CsA; AZA; Steroids	Everolimus; CsA; Steroids	Excision, curettage, and photodynamic therapy	24 months	No lesions (12 months)
Alter et al. 2014 [67]	62/kidney	SCC (1), BCC (1), BD (4)	66	AZA; Steroids	Everolimus; Steroids	Excision, curettage, and photodynamic therapy	24 months	No lesions
Alter et al. 2014 [67]	57/heart	BD (2)	120	CsA; AZA; Steroids	Everolimus; CsA; Steroids	Excision, curettage, and photodynamic therapy	24 months	No lesions

Use of steroids before or after conversion to everolimus was not stated.
AZA, azathioprine; BCC, basal cell carcinoma; BD, Bowen's disease; CsA, cyclosporine; IS, immunosuppressive; MMF, mycophenolate mofetil; NSMC, nonmelanoma skin cancer; SCC, squamous cell carcinoma; tx, transplantation.