Immunomodulatory Role of Mesenchymal Stem Cell Therapy in Vascularized Composite Allotransplantation

Table 2

The Banff 2007 working classification of skin-containing composite tissue allograft pathology [39].

Banff Grade	Rejection severity	Histopathological features
0	No rejection	No or rare inflammatory infiltrates
1	Mild	Mild perivascular infiltration and no involvement of the overlying epidermis
2	Moderate	Moderate-to-severe perivascular inflammation with or without mild epidermal and/or adnexal involvement
		No epidermal dyskeratosis or apoptosis
3	Severe	Dense inflammation and epidermal involvement with epithelial apoptosis, dyskeratosis, and/or keratinolysis
4	Necrotizing acute rejection	Frank necrosis of epidermis or other skin structures