Liver Transplantation for Hepatocellular Carcinoma: A Single Center Resume Overlooking Four Decades of Experience

Table 6

Identification of hazards for HCC recurrence related deaths by univariate Cox regression, (non-HCC recurrence related deaths excluded).

Univariate Cox regressions for HCC recurrence related deaths				exp()/hazard	95.0% CI
					Lower	Upper
Underlying disease	Hepatitis B with D	11	0.348	Reference category
	Hepatitis B	50	0.368	1.964	0.451	8.553
	Hepatitis C	55	0.542	1.584	0.361	6.939
	Hepatitis C with B	6	0.908	0.868	0.079	9.588
	Alcohol	30	0.162	2.919	0.65	13.109
	Cryptogenic cirrhosis	30	0.13	3.151	0.714	13.896
	Other	17	0.433	1.93	0.373	9.979
Tumor vitality	Vital tumor	168	0.083	Reference category
	Full-necrotic tumor	17	0.147	0.352	0.086	1.442
	No tumor detectable	14	0.084	0.175	0.024	1.264
Tumor morphology	No tumor detectable	14	<0.001	Reference category
	Uninodular	89	0.323	2.765	0.368	20.791
	Multinodular unilateral	41	0.104	5.354	0.707	40.567
	Multinodular bilateral	55	0.019	10.898	1.488	79.801
UICC-7	No or necrotic tumor	31	<0.001	Reference category
	UICC I	54	0.688	0.746	0.178	3.124
	UICC II	51	0.402	1.738	0.477	6.327
	UICC IIIA	21	0.003	6.771	1.944	23.584
	UICC IIIB	26	<0.001	12.792	3.791	43.16
	UICC IIIC	6	0.006	8.066	1.800	36.142
	UICC IVA	7	<0.001	226.972	46.041	1118.915
	UICC IVB	3	<0.001	91.043	16.824	492.692
hMILAN	Inside	112	Reference category
	Outside	87	<0.001	4.701	2.700	8.185
Vascular infiltration	No or necrotic tumor	31	<0.001	Reference category
	V0	117	0.371	1.733	0.52	5.779
	V1	21	<0.001	9.578	2.769	33.128
	V2	30	<0.001	14.066	4.221	46.866
Neoadj. therapy	No	82	Reference category
	Yes	117	0.010	0.525	0.321	0.859
Grading	No or necrotic tumor	31	<0.001	Reference category
	G1	26	0.26	2.179	0.562	8.442
	G2	103	0.061	3.098	0.948	10.124
	G3-4	36	0.001	7.909	2.357	26.542
	Missing data	3	0.007	11.921	1.980	71.774

HCC = hepatocellular carcinoma.
UICC-7 = 7th edition TNM classification of Unité International Contre Cancer.
hMILAN = histologic MILAN classification.
Vascular infiltration: V0 = none, V1 = small vessels, and V2 = large vessels.
Tumor grading: G1 = low, G2 = intermediate, and G3-4 = high to anaplastic.