Blood Transfusions and Tumor Biopsy May Increase HCC Recurrence Rates after Liver Transplantation

Table 2

Univariate and multivariate values of tumor and nontumor related risk factors for HCC recurrence after LT. The nontumor related risk factors were analyzed stratified for the most dominant tumor related risk factor (microvascular invasion).

	Univariate	Multivariate
Tumor factors:
Microvascular invasion	<0.001	<0.001
Number of tumor nodules (≤3 versus >3)	<0.001	0.138
Maximum diameter (≤5 versus >5 cm)	0.001	0.934
AFP level	0.006	0.495
HCC incidentally detected after LT	0.108
Nontumor factors:
Tumor biopsy	0.015	0.884
Blood transfusions	0.023	0.033
Age (≤60 versus >60 years)	0.045	0.118
Waiting time	0.091
Child Pugh status	0.175
Sirolimus after LT	0.183
Underlying liver disease	0.208
Cyclosporine (versus tacrolimus)	0.280
Haemodialysis	0.343
Immunosupp. (dual versus triple versus quadruple)	0.362
ATG induction therapy	0.398
Pervious liver resection for HCC	0.481
Gender	0.496
OKT 3 therapy	0.524
Piggy back	0.567
Azathioprine	0.571
IL-2 induction therapy	0.614
Antirejection therapy (antibodies, steroids)	0.646
Mycophenolate	0.674
Duration of ICU treatment	0.746
Period of LT	0.859
Blood group	0.891
TACE before LT	0.960