Research Article
Reversibility of Frailty after Lung Transplantation
Table 2
Comparison of demographics and baseline prognostic markers of a study population stratified by physical frailty status.
| | | Total (n = 166) | Nonfrail (n = 139) | Frail (n = 27) | value |
| | Age (years) | 54 (21) | 54 (21) | 54 (22) | NS | | Gender, male (%) | 90 (54%) | 79 (57%) | 11 (41%) | NS | | Diagnosis | | CF | 39 (23%) | 35 (25%) | 4 (15%) | NS | | COPD/AAT | 54 (33%) | 48 (35%) | 6 (22%) | | | ILD | 50 (30%) | 39 (28%) | 11 (40%) | | | PAH | 5 (3%) | 4 (3%) | 1 (4%) | | | CLAD | 8 (5%) | 4 (3%) | 4 (15%) | | | CHD | 4 (2%) | 3 (2%) | 1 (4%) | | | Others | 6 (4%) | 6 (4%) | 0 | | | Transplant type | | Bilateral lung | 159 (96%) | 134 (96%) | 25 (93%) | NS | | Single lung | 4 (2.4%) | 2 (1.4%) | 2 (7%) | | | Heart-lung | 3 (1.6%) | 3 (2.6%) | 0 | | | Serum creatinine (μmol/L) | 73 ± 21 | 75 ± 21 | 65 ± 19 | 0.02 | | eGFR (ml/min/m2) | 82 ± 12 | 82 ± 12 | 84 ± 11 | NS | | Serum bilirubin (μmol/L) | 10 ± 9 | 10 ± 10 | 6 ± 4 | NS | | Serum albumin (g/L) | 43 ± 5 | 44 ± 5 | 40 ± 6 | <0.001 | | Hypoalbuminaemia, n (%) | 8 (5%) | 4 (3%) | 4 (15%) | 0.03 | | Haemoglobin (g/L) | 141 ± 19 | 143 ± 18 | 129 ± 22 | 0.001 | | Anemia, n (%) | 18 (11%) | 10 (7%) | 8 (30%) | 0.003 | | Abnormal MOCA, n (%) | 42 (25%) | 31 (22%) | 11 (41%) | 0.04 | | Abnormal DMI, n (%) | 48 (29%) | 33 (24%) | 15 (56%) | 0.001 | | PaO2 (mmHg) | 64 ± 11 | 64 ± 10 | 64 ± 15 | NS | | FEV1 (% predicted) | 39 ± 21 | 39 ± 21 | 39 ± 19 | NS | | FVC (% predicted) | 65 ± 20 | 67 ± 19 | 56 ± 17 | 0.008 |
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