Orthostatic Hypotension and Concurrent Autonomic Dysfunction: A Novel Complication of Lung Transplantation

Table 1

Baseline characteristics, pretransplant clinical features, and outcomes in the study cohort.

Variables	Study cohort, n = 13
Age, years^†	68 (66, 71)
Gender, male	12, 92.3
Height, inches^†	70 (68, 72.5)
Body mass index, kg/m^2†	26.6 (22.8, 28.9)
Lung transplant, bilateral	12, 92.3
Underlying diagnosis
IPF	9, 69.2
COPD	3, 23.1
CPFE	1, 7.7
Pre-LTx clinical features
LAS^†	47.5 (35.4, 54.7)
Creatinine, mg/dL^†	0.8 (0.8, 1.2)
Distance walked in six minutes, meters^†	346 (273, 393)
Right atrial pressure, mmHg^†	7.5 (4, 12.5)
Mean pulmonary artery pressure, mmHg^†	22 (20, 33)
Pulmonary capillary wedge pressure, mmHg^†	15 (6, 19)
Cardiac index	3.3 (2.9, 3.7)
Known orthostatic hypotension	1, 7.7
Arrhythmia	4, 30.8
Preexisting peripheral neuropathy	3, 23.1
Preexisting gastroparesis	2, 15.4
Immunosuppression
Induction: basiliximab	10, 76.9
Induction: rituximab/IVIG	2, 15.4
Induction: ATG	1, 7.7
Mycophenolate mofetil, tacrolimus, steroids	13, 100
Cyclosporin	1, 7.7
Belatacept	1, 7.7
Post-LTx clinical features
Primary graft dysfunction grade 3	4, 30.8
Time to endotracheal extubation, days^†	4 (1, 6)
Atrial fibrillation in first postoperative week	9, 69.2
Decrease in SBP supine to standing^†	56 (38, 66)
Decrease in DBP supine to standing^†	25 (10.5, 40)
Supine hypertension	10, 76.9
Discharged to home	3, 23.1
Inpatient rehabilitation after LTx	10, 76.9
Readmissions for inpatient rehabilitations	3, 23.1
Number of readmissions in first year^†	2 (1, 3)
Length of stay for readmissions, days^†	18 (13, 29)
Deaths	6, 46.2
1^st year	3, 23.1
2^nd year	2, 15.4
3^rd year	1, 7.7

Data expressed as numbers, percentages unless specified otherwise; ^†data expressed as median (interquartile range). IPF, idiopathic pulmonary fibrosis; COPD, chronic obstructive pulmonary disease; CPFE, combined pulmonary fibrosis and emphysema; LTx, lung transplant; LAS, lung allocation score; IVIG, intravenous immunoglobulin; ATG, rabbit antithymocyte globulin; SBP, systolic blood pressure; DBP, diastolic blood pressure.