Kidney Retransplantation after Graft Failure: Variables Influencing Long-Term Survival
Table 3
Risk factors for graft loss in first and second transplantation.
HR
95% CI
value
Number of transplantations
1
Ref
2
1.5
1.1–2.0
0.003
≥3
3.3
1.7–6.1
<0.001
Recipient age (years)
<50
Ref
50–59
1.2
0.9–1.6
0.1
60–69
1.9
1.4–2.5
<0.001
≥70
2.9
1.8–4.8
<0.001
Time on dialysis (years)
<1
Ref
1-2
1.2
0.9–1.5
0.2
2–4
1.4
1.1–1.8
0.003
>4
1.7
1.3–2.2
<0.001
Charlson–Deyo index
2 (kidney disease only)
Ref
3 (≤1 mild comorbidity)
1.2
0.9–1.6
0.1
4 (≥2 mild or 1 moderate comorbidity)
1.8
1.4–2.4
<0.001
≥5 (multiple comorbidities)
2.3
1.7–3.0
<0.001
Smoking
1.3
1.1–1.5
0.01
Comorbidities
Myocardial infarction
1.3
1.0–1.7
0.04
Congestive heart failure
3.1
2.1–4.5
<0.001
PAD
1.4
1.0–1.8
0.03
Diabetes with end organ failure
1.2
1.0–1.3
0.02
Moderate – severe liver disease
1.3
1.0–1.6
0.04
Note. HR, hazard ratio; CI, confidence interval; PAD, peripheral artery disease. Charlson–Deyo index was analyzed for scoring points and in a second model using the same confounders for underlying comorbidities to avoid interactions.
