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Journal of Veterinary Medicine
Volume 2015 (2015), Article ID 412501, 9 pages
Research Article

An Antioxidant Dietary Supplement Improves Brain-Derived Neurotrophic Factor Levels in Serum of Aged Dogs: Preliminary Results

1Department of Veterinary Medicine, Pathology and Veterinary Clinic Section, Via Vienna 2, 07100 Sassari, Italy
2SANYpet S.p.a., Research and Development Department, Via Austria 3, Bagnoli di Sopra, 35023 Padua, Italy
3School of Specialization in Clinical Biochemistry, “G. d’Annunzio” University, Via dei Vestini 31, 66100 Chieti, Italy

Received 23 March 2015; Revised 1 June 2015; Accepted 7 June 2015

Academic Editor: Antonio Ortega-Pacheco

Copyright © 2015 Sara Sechi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Biological aging is characterized by a progressive accumulation of oxidative damage and decreased endogenous antioxidant defense mechanisms. The production of oxidants by normal metabolism damages proteins, lipids, and nucleotides, which may contribute to cognitive impairment. In this study 36 dogs were randomly divided into four groups and fed croquettes of different compositions for 6 months. We monitored derivatives of reactive oxygen metabolites (dROMs) and biological antioxidant potential (BAP) levels in dogs’ plasma samples as well as brain-derived neurotrophic factor (BDNF) serum levels at the beginning and at the end of the dietary regime. Our results showed that a dietary regime, enriched with antioxidants, induced a significant decrease of plasma levels of dROMs () and a significant increase in BDNF serum levels () after six months. Thus, we hypothesized a possible role of the diet in modulating pro- and antioxidant species as well as BDNF levels in plasma and serum, respectively. In conclusion the proposed diet enriched with antioxidants might be considered a valid alternative and a valuable strategy to counteract aging-related cognitive decline in elderly dogs.