Table of Contents
Leukemia Research and Treatment
Volume 2012, Article ID 262363, 4 pages
Clinical Study

Diffuse Large B-Cell Lymphoma in Human T-Lymphotropic Virus Type 1 Carriers

1Department of Oncology and Radiotherapy, Edgardo Rebagliati Martins Hospital, Lima, Peru
2Department of Pathology, Edgardo Rebaglati Martins Hospital, Lima, Peru
3Department of Oncology, Daniel Alcides Carrion Hospital, Lima, Peru
4Division of Hematology and Oncology, The Miriam Hospital, Brown University Warren Alpert Medical School, Fain Building, 164 Summit Avenue, Providence, RI 02906, USA

Received 1 August 2011; Accepted 21 September 2011

Academic Editor: Kunihiro Tsukasaki

Copyright © 2012 Brady E. Beltran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We describe the clinical and pathological characteristics of seven patients who were human T-lymphotropic virus type 1 (HTLV-1) carriers and had a pathological diagnosis of de novo diffuse large B-cell lymphoma. Interestingly, three of our cases showed positive expression of Epstein-Barr-virus, (EBV-) encoded RNA within the tumor cells indicating a possible interaction between these two viruses. Furthermore, our three EBV-positive cases presented with similar clinical characteristics such as early clinical stage and low-risk indices. To the best of our knowledge, this is the first case series describing the characteristics of HTLV-1-positive DLBCL patients. The potential relationship between HTLV-1 and EBV should be further explored.