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Mediators of Inflammation
Volume 1, Issue 5, Pages 295-308
http://dx.doi.org/10.1155/S0962935192000449

Interactions between rnacrophage cytokines and eicosanoids in expression of antitumour activity

1Department of Pharmacology, Faculty of Medicine, Erasmus University, Rotterdam 3000 DR, The Netherlands
2 Department of Human Microbiology, Sackler School of Medicine, TeI-Aviv University, TeI-Aviv 69978, Israel

Copyright © 1992 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cytokines and eicosanoid products of macrophages play an essential role in expression of antitumour activity of macrophages either in a cell-to-cell contact system between the effector and the target cell or as cell-free soluble products. In this review the relationship between three main monokines, namely TNF-α, IL-1 and IL-6 and the interrelationship between these monokines and eicosanoids (PGE2, PGI2, LTB4, LTC4) in their production and in expression of antitumour activity is discussed. Emphasis is given to the effect of tumour burden on production of the monokines and of the eicosanoids and on the production of these compounds by the tumour cells. Finally, the therapeutic implications drawn from animal studies and clinical trials is discussed.