Mediators of Inflammation

Mediators of Inflammation / 1993 / Article
Special Issue

Supplement 1 August 1993 Carnitine and Congeners as Regulators of Tumour Necrosis Factor Guest Editors - C De Simone, E Arrigoni Martelli and P Foresta

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Research paper | Open Access

Volume 2 |Article ID 560685 | https://doi.org/10.1155/S0962935193000766

Linda L. Gallo, Yan Tian, Zaven Orfalian, Gary Fiskum, "Amelioration of popolysaccharide-induced sepsis in rats by free and esterified carnitine", Mediators of Inflammation, vol. 2, Article ID 560685, 6 pages, 1993. https://doi.org/10.1155/S0962935193000766

Amelioration of popolysaccharide-induced sepsis in rats by free and esterified carnitine

Abstract

The purpose of this study was to determine if free or esterified carnitine could alter fatty acid metabolism and ameliorate sepsis in lipopolysaccharide (LPS)-treated rats. Throughout a 96 h observation post-LPS, i.p. administration of both markedly reduced illness and accelerated recovery. Carnitine prevented the acute LPS-induced rise in serum triglycerides (45 ± 6, 59 ± 5 vs. 83 ± 8 mg/ml, p < 0.001), respectively. This difference was accompanied by a significant increase in liver lipogenesis in LPS controls compared to both carnitines and normal rats (6.1 ± 0.3 vs. 3.9 ± 0.5, 4.3 ± 0.5, and 1.8 ± 0.4 μmol/h, respectively, p < 0.04). Compared to normal rats, total liver carnitine was significantly elevated in LPS controls and even higher in the carnitine groups (357 ± 40 vs. 736 ± 38, 796 ± 79, and 1081 ± 21 nmol/g). The data suggest that carnitines may be of therapeutic value in sepsis treatment and one action may be to partition fatty acids from esterification to oxidation.

Copyright © 1993 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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