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Mediators of Inflammation
Volume 2, Issue 7, Pages S29-S32
Research paper

L-carnitine: a partner between immune response and lipid metabolism ?

1Infectious Diseases, Via S. Sisto, University of L'Aquila, 67100, Italy
2Department of Internal Medicine and Public Health, Via S. Sisto, University of L'Aquila, 67100, Italy
3Infectious Diseases, University “La Sapienza” Rome, Italy
4Sigma Tau, Pomezia, Italy

Copyright © 1993 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The authors demonstrated that in vivo administered L-carnitine strongly ameliorated the immune response in both healthy individuals receiving Intralipid and ageing subjects with cardiovascular diseases, as shown by the enhancement of mixed lymphocyte reaction. Notably, in the latter group L-carnitine treatment also resulted in a significant reduction of serum levels of both cholesterol and triglycerides. Therefore, the hypothesis is that L-carnitine supplementation could ameliorate both the dysregulated immune response and the abnormal lipid metabolism in several conditions.