Mediators of Inflammation

Mediators of Inflammation / 1993 / Article

Research paper | Open Access

Volume 2 |Article ID 906142 | https://doi.org/10.1155/S0962935193000614

C. Zoja, A. Benigni, G. Piccinini, M. Figliuzzi, L. Longaretti, G. Remuzzi, "Interleukin-6 stimulates gene expression of extracellular matrix components in bovine mesangial cells in culture", Mediators of Inflammation, vol. 2, Article ID 906142, 5 pages, 1993. https://doi.org/10.1155/S0962935193000614

Interleukin-6 stimulates gene expression of extracellular matrix components in bovine mesangial cells in culture

Received26 Jul 1993
Accepted20 Sep 1993

Abstract

The effect of interleukin-6 (IL-6) on gene expression of extracellular matrix components in bovine mesangial cells in culture has been investigated. IL-6 (100 U/ml) time dependently increased the steady state expression of mRNAs coding for α1 collagen III and fibronectin, both transcripts being 1.5- and 2.5-fold higher than basal level at 24 and 48 h, respectively. In contrast, IL-6 stimulated laminin mRNA expression only after 48 h incubation (2.5-fold upon basal level). These results suggest that IL-6 could favour glomerular matrix accumulation thus contributing to the development of glomerulosclerosis.

Copyright © 1993 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


More related articles

 PDF Download Citation Citation
 Order printed copiesOrder
Views116
Downloads280
Citations

Related articles

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.