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Mediators of Inflammation
Volume 2, Issue 2, Pages 99-102

Phospholipid derived mediators and glomerulonephritis

21 Common Road, North Leigh, Oxon, OX8 6RD, UK

Received 14 January 1993; Accepted 15 February 1993

Copyright © 1993 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The contributions made by the various eicosanoids, PAF, the HETES and the lipoxins to the pathophysiology of glomerulonephritis is reviewed. A case can be made for clinical trials of PAF, leukotriene and thromboxane antagonists. Combined thromboxane synthetase and thromboxane receptor antagonism would seem to be the more efficacious approach for the various disease entities.