Supplement 1–Sodium Cromoglycate and Nedocromil in Respiratory Inflammation of
Children Workshop; Ancona, 19 March 1994 Guest Editors—P L Giorgi and J C de Jongste
Effect of Nedocromil Sodium on Polymorphonuclear Leukocyte Plasma Membrane
A. Kantar,1N. Oggiano,1P. L. Giorgi,1G. V. Coppa,1R. Gabbianelli,1S. Bruni,1F. M. Cutrona,1and R. Fiorini2
Abstract
The effect of nedocromil sodium on the plasma membrane fluidity of
polymorphonuclear leukocytes (PMNs) was investigated by measuring
steady-state fluorescence anisotropy of
1-[4-trimethylammonium-phenyl]-6-phenyl- 1,3,5-hexatriene (TMA-DPH)
incorporated in the membrane. Our results show that nedocromil
sodium 300 μM significantly decreased membrane fluidity of PMNs.
The decrease in membrane fluidity of PMNs induced by fMLP was
abolished in the presence of nedocromil sodium. These data suggest
that nedocromil sodium interferes with the plasma membranes of PMNs
and modulates their activities.
