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Mediators of Inflammation
Volume 3, Issue 7, Pages S21-S24

Effect of Nedocromil Sodium on Polymorphonuclear Leukocyte Plasma Membrane

1Department of Paediatrics , University of Ancona, Via Corridoni II, Ancona I-60123, Italy
2Department of Biochemistry, University of Ancona, Via Corridoni II, Ancona I-60123, Italy

Copyright © 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The effect of nedocromil sodium on the plasma membrane fluidity of polymorphonuclear leukocytes (PMNs) was investigated by measuring steady-state fluorescence anisotropy of 1-[4-trimethylammonium-phenyl]-6-phenyl- 1,3,5-hexatriene (TMA-DPH) incorporated in the membrane. Our results show that nedocromil sodium 300 μM significantly decreased membrane fluidity of PMNs. The decrease in membrane fluidity of PMNs induced by fMLP was abolished in the presence of nedocromil sodium. These data suggest that nedocromil sodium interferes with the plasma membranes of PMNs and modulates their activities.