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Mediators of Inflammation
Volume 4, Issue 2, Pages 95-97

Group II phospholipase A2 in human gingiva with periodontal disease

1Department of Periodontology and Endodontology, School of Dentistry, the University of Tokushima, 3 Kuramoto-cho, Tokushima 770, Japan
2Department of Molecular Physiological Chemistry, Osaka University Medical School, 2 Yamadaoka, Suita, Osaka 565, Japan

Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Fourteen kilodalton phospholipase A2 molecules (PLA2) are classified into two groups, I- and II-PLA2, and only the latter has been considered to play a pathogenetic role in various forms of tissue inflammation. Previously we demonstrated high PLA2 activity in gingival crevicular fluid (GCF) of patients with periodontal disease, without determining the group of the enzyme involved. In this study, the activity, groups and levels of enzyme in gingiva taken from 13 sites of periodontal disease were determined using both biochemical and radioimmunological methods. A linear correlation between the activity and the level of II-PLA2 was observed. No I-PLA2 was found in any of the samples tested. These data suggest that the PLA2 activity found in the GCF of patients with periodontal disease does not belong to the I-PLA2 but to the II-PLA2 group.