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Mediators of Inflammation
Volume 4, Issue 5, Pages 368-373
http://dx.doi.org/10.1155/S0962935195000603

Tumour necrosis factor-α in nasal allergy

1Department of Otorhinolaryngology , Yamanashi Medical University, 1110 Shimokato, Tamaho-cho, Nakakoma-gun, Yamanashi-ken 409-38, Japan
2Second Department of Biochemistry, Yamanashi Medical University, 1110 Shimokato, Tamaho-cho, Nakakoma-gun, Yamanashi-ken 409-38, Japan

Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Tumour necrosis factor-α (TNF-α) was measured by enzyme-linked immunosorbent assay and eosinophil cationic protein (ECP) by radio-immunoassay to evaluate TNF-α in nasal allergy. There was no significant difference either between the mean concentrations of TNF-α in nasal secretions from the patients with perennial nasal allergy and those of normal subjects, or between the TNF-α and ECP concentrations. However, reverse transcription polymerase chain reaction showed a specific increase of TNF-α mRNA and IFN-γ mRNA in allergic nasal mucosa after allergen challenge in vitro. These findings suggest a possibility that T cell-derived IFN-γ up-regulates macrophages to elaborate TNF-α, which may play a role in amplifying allergic inflammation in the nose through the cytokine network.