K. Hisamatsu, T. Ganbo, T. Nakazawa, S. Horiguchi, S. Shimomura, Y. Murakami, "Elevation of soluble interleukin-2 receptor levels in nasal allergy", Mediators of Inflammation, vol. 4, Article ID 949643, 4 pages, 1995. https://doi.org/10.1155/S096293519500007X
Elevation of soluble interleukin-2 receptor levels in nasal allergy
To investigate soluble IL-2 receptor (sIL-2R) levels in nasal allergy, the sera and nasal secretions from patients with nasal allergy and from healthy subjects were subjected to a double-epitope enzyme-linked immunosorbent assay. Significant elevation of sIL-2R concentrations in the sera and nasal secretions was observed in the allergy patients (n = 26) compared with those of healthy subjects (n = 9). IL-2R-positive (CD25+) cells were observed in the crust formed in an allergic nasal mucosa. The concentration of sIL-2R in the sera correlated neither with the eosinophil count of the peripheral blood count nor with clinical severity. The concentration of sIL-2R in the nasal secretions was significantly higher compared with that in the sera from allergic patients (p < 0.01), whereas no significant difference was observed between sIL-2R levels in the sera and nasal sections from normal subjects. These findings indicate that sIL-2R plays an essential role in allergic processes by regulating IL-2R-positive cells recruited into the nasal mucosa.
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