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Mediators of Inflammation
Volume 5, Issue 6, Pages 429-433

Changes in TNF and IL-6 production after diphtheria toxoid vaccination: drug modulation of the cytokine levels

1Research Centre for Medical Genetics, 1 Moskvorechie Street, Moscow 115478, Russia
2Moscow Institute of Epidemiology and Microbiology, Moscow, Russia
3National Institute of Epidemiology, Moscow, Russia

Copyright © 1996 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The effect of vaccination with diphtheria toxoid (AD-M) on TNF and IL-6 production has been studied in humans. In the present study it was demonstrated that immunization with AD-M resulted in changes of in vitro TNF and IL-6 production by peripheral blood mononuclear cells. TNF release was suppressed but IL-6 production was stimulated. On the other hand, serum levels of TNF were markedly increased over a period of 3 weeks. It was also demonstrated that the postvaccinal cytokine production disturbances may be corrected by pretreatment with a new synthetic hexapeptid (Imunofan®). It is possible that the imunofan treatment could prevent some postvaccinal complications.