Mediators of Inflammation

Mediators of Inflammation / 1996 / Article

Open Access

Volume 5 |Article ID 845412 |

R. Debets, H. F. J. Savelkoul, "Cytokines as cellular communicators", Mediators of Inflammation, vol. 5, Article ID 845412, 7 pages, 1996.

Cytokines as cellular communicators


Cytokines and their receptors are involved in the pathophysiology of many diseases. Here we present a detailed review on cytokines, receptors and signalling routes, and show that one important lesson from cytokine biology is the complex and diverse regulation of cytokine activity. The activity of cytokines is controlled at the level of transcription, translation, storage, processing, posttranslational modification, trapping, binding by soluble proteins, and receptor number and/or function. Translation of this diverse regulation in strategies aimed at the control of cytokine activity will result in the development of more specific and selective drugs to treat diseases.

Copyright © 1996 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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