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Mediators of Inflammation
Volume 6 (1997), Issue 4, Pages 279-283
http://dx.doi.org/10.1080/09629359791622

Pharmacokinetics, biological effects, and distribution of (1→3)-β-D-glucan in blood and organs in rabbits

1Fourth Depar tmentof Internal Medicine, Teikyo University School of Medicine, 74 Mizonokuchi, Takatsu-ku, Kawasaki City 213, Japan
2Department of Laboratory Medicine, Metabolism Section, University of California School of Medicine, the Veterans Administration Medical Center, San Francisco 94121, CA, USA
3Department of Medicine, Metabolism Section, University of California School of Medicine, the Veterans Administration Medical Center, San Francisco 94121, CA, USA

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The pharmacokinetics, biological effects and distribution in blood and organs of 125I-labeled (1→3)-β-D-glucan purified from Candida albicans were analyzed in rabbits during the 24-h period following an intravenous administration.The intravascular half-life of (1→3)-β- D-glucan was 1.8 min in the low-dose group (9.3 μg/kg) and 1.4 min in the high-dose group (222 μg/kg), and the mean (±SD) total body clearance was 1.12 ± 0.30 and 1.17 ± 0.16 ml/min, respectively. The rabbits remained well and (1→3)-β-D-glucan failed to alter blood cell counts. Less than 3% of the 125I-(1→3)-β-D-glucan was initially associated with the cellular compartment, and this value decreased further during the 2-h period following administration (P = 0.0001). Over 97% of 125I-(1→3)-β-D-glucan was associated with cell-free plasma, and the majority in plasma appeared to be present in the unbound form (not associated with lipoproteins or plasma proteins). The liver contained more than 80% of the 125I-(1→3)-β-D-glucan detected in the six major organs analyzed.