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Mediators of Inflammation
Volume 6 (1997), Issue 1, Pages 69-72

Effects of anabolic steroids on acute phase responses in intra-abdominal sepsis

1Department of Surgery, Trinity College and St James's Hospital, Dublin, Ireland
2Department of Immunology, St James's Hospital and Dublin Institute of Technology, Dublin, Ireland
3Department of Surgery, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The acute phase response is an important adaptive response to sepsis and injury. As anabolic steroids increase protein synthesis we postulated that these agents might also increase hepatic acute phase protein synthesis. Male Wistar rats were pretreated with testosterone or danazol for 48 h prior to caecal ligation and puncture (CLP). Thirty-six h following surgery the animals were killed and blood taken for full blood count, total protein, albumin, α, β and γ globulin fractions on serum electrophoresis, complement C3 and transferrin levels. Danazol increased the α1, α2 and β1 globulin serum protein fractions in comparison with no surgery and CLP alone groups. These results indicate that danazol increases plasma acute phase proteins, as measured by electrophoresis, in this model of intra-abdominal sepsis.