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Mediators of Inflammation
Volume 6, Issue 4, Pages 271-273

(1→3)-β-D-glucanemia in deep mycosis

Department of Clinical Pathology, Jichi Medical School, 3311-1 Yakushiji, Minamikawachi-machi, Kawachi-gun, Tochigi 329-04, Japan

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Factor G, a coagulation proenzyme of the Japanese horseshoe crab (Tachypleus tridentatus), is extremely sensitive to (1→3)-β-D-glucan, which is a characteristic cell-wall constituent of fungi. Using this factor and by a digestion study with (1→3)-β-D-glucan, we showed that blood from patients with deep m ycosis contains the glucan. It was detected in 39 out of 41 fungal febrile episodes (sensitivity 90%), but in none of the 59 nonfungal febrile episodes (specificity 100%).