Mediators of Inflammation

Mediators of Inflammation / 1997 / Article

Open Access

Volume 6 |Article ID 806907 |

H. Ijsselstijn, F. J. Zijlstra, J. C. De Jongste, D. Tibboel, "Prostanoids in bronchoalveolar lavage fluid do not predict outcome in congenital diaphragmatic hernia patients", Mediators of Inflammation, vol. 6, Article ID 806907, 8 pages, 1997.

Prostanoids in bronchoalveolar lavage fluid do not predict outcome in congenital diaphragmatic hernia patients


Vasoactive prostanoids may be involved in persistent pulmonary hypertension (PPH) in infants with a congenital diaphragmatic hernia (CDH). We hypothesized that increased levels of prostanoids in bronchoalveolar lavage (BAL) fluid would predict clinical outcome. We measured the concentrations of 6-keto-prostaglandin F (6-keto-PGF), thromboxane B2 (TxB2), protein, albumin, total cell count, and elastase-α1-proteinase-inhibitor complex in BAL fluid of 18 CDH patients and of 13 control subjects without PPH. We found different concentrations of prostanoids in BAL fluid of CDH patients with PPH: infants with a poor prognosis had either high levels of both 6-keto-PGF and TxB2 compared to controls, or high levels of 6-keto-PGF only. TxB2 levels showed a large variability in all CDH patients irrespective of outcome. We conclude that prostanoid levels in BAL fluid do not predict clinical outcome in CDH patients.

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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