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Mediators of Inflammation
Volume 6, Issue 4, Pages 263-265

Inhalation toxicity of (1→3)-β-D glucan: recent advances

1Department of Environmental Medicine, University of Gothenburg, Medicinaregatan 16, Gothenburg S-413 90, Sweden
2Department of Surgery, James H. Quillen College of Medicine, Johnson City, Tennessee, USA

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


To investigate the effects of (1→3)-β-D-glucan after inhalation, animals were exposed to different forms of glucan and the number of lung lavage cells was determined 24 h after exposure. None of the different forms assayed caused any increase in cell numbers. In animals exposed to endotoxin, all types of cells were increased after 24 h. A simultaneous exposure to curdlan reduced this increase in a dose-related fashion. The results suggest that (1→3)-β-D-glucan-related acute injury to the lung is induced by mechanisms other than those induced by inflammagenic agents such as endotoxin.