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Mediators of Inflammation
Volume 7, Issue 3, Pages 211-215
http://dx.doi.org/10.1080/09629359891153

Constitutive expression of E-and P-selectin cognate ligands in human endothelial cells

1Menarini Ricerche S.p.A. Department of Pharmacology, Via Tito Speri 10, Pomezia, Rome 00040, Italy
2Istituto Patologia Generale, Università degli Studi di Firenze, Viale Morgagni 50, Firenze 50134, Italy

Copyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

On human endothelial cells from umbilical cord (HUVEC) are present, in addition to E-and P-selectins, their cognate ligands. Differently from selectins, the ligand expression is constitutive and not modulated by interleukin-1β . Such ligands appear to be different from the ones present in promyelocytic cells in order to promote cell adhesion to immobilized selectins. The expression of selectin-ligands on HUVEC cells suggest that selectins can participate in endothelial signalling besides their role as adhesion molecules for circulating blood cells. However, despite their role in chemotaxis, selectins do not contribute to HUVEC tube formation in Matrigel.