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Mediators of Inflammation
Volume 7 (1998), Issue 6, Pages 413-415
http://dx.doi.org/10.1080/09629359890794

Possible in vivo tolerance of human polymorphonuclear neutrophil to low-grade exercise-induced endotoxaemia

1Center for the Biochemistry of Oxygen, University of Liège, Liège, Belgium
2Institute of Chemistry, University of Liège, Liège, Belgium
3Department of Anaesthesiology and Intensive Care Medicine, University of Liège, Liège, Belgium
4Department of Clinical Biology, University of Liège, Liège, Belgium
5Physiological Chemistry, ISEPK, Brugmann Hospital Université Libre de Bruxelles, Brussels, Belgium
6Department of Immunology, Brugmann Hospital Université Libre de Bruxelles, Brussels, Belgium
7Research Associate , National Fund for Medical Research, Belgium

Copyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

To address the question of whether translocation of bacterial lipopolysaccharide (LPS) into the blood could be involved in the process of exercise-induced polymorphonuclear neutrophil (PMN) activation, 12 healthy male subjects who took part in a sprint triathlon (1.5 km river swim, 40 km bicycle race, 10 km road race) were studied. While there was no detectable amount of endotoxin in the blood samples drawn at rest, exercise was followed by the appearance of circulating endotoxin molecules at the end of competition in four subjects, and after one and 24 h recovery in three and seven athletes, respectively. The concentrations of plasma granulocyte myeloperoxidase ([MPO]), were significantly higher immediately after exercise and one hour later than baseline values (P<0.001). This variable returned to pre-race levels the day after exercise, despite the presence of detectable amounts of LPS, at that time, in seven athletes. The absence of significant correlation (r=0.26;P=0.383) and temporal association between [MPO]and plasma endotoxin levels led us to conclude that endotoxaemia was not involved in the process of exercise-induced PMN degranulation observed in our subjects.