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Mediators of Inflammation
Volume 8, Issue 2, Pages 93-100
http://dx.doi.org/10.1080/09629359990586

Estimation of SLE Activity Based on the Serum Level of Chosen Cytokines and Superoxide Radical Generation

Department of Dermatology and Venereology, Medical University of Lodz, Krzemieniecka 5, Lodz 94–017, Poland

Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We estimated the serum levels of IL-6, TNF-α and IL10, and generation of superoxide radicals, as well as their mutual dependence, in 63 SLE patients at various stages of disease activity. Our results indicate a statistically significant increase of the serum levels studied, and an increase of superoxide anion generation by granulocytes, in correlation with SLE activity. These results indicate that oxygen metabolism and the examined cytokines play an important role in pathogenesis of SLE. The assessment of these parameters can be useful in the estimation of disease activity.