Mediators of Inflammation

Mediators of Inflammation / 2001 / Article

Open Access

Volume 10 |Article ID 910914 |

Rijn Q. Jöbsis, Susanne L. Schellekens, Anoeska Fakkel-Kroesbergen, Rolien H. C. Raatgeep, Johan C. de Jongste, "Hydrogen peroxide in breath condensate during a common cold", Mediators of Inflammation, vol. 10, Article ID 910914, 4 pages, 2001.

Hydrogen peroxide in breath condensate during a common cold


Background: Hydrogen peroxide (H2O2) in exhaled air condensate is elevated in inflammatory disorders of the lower respiratory tract. It is unknown whether viral colds contribute to exhaled H2O2.Aim: To assess exhaled H2O2 during and after a common cold.Methods: We examined H2O2 in the breath condensate of 20 normal subjects with acute symptoms of a common cold and after recovery 2 weeks later and, similarly, in 10 subjects without infection. H2O2 was measured with a fluorimetric assay.Results: At the time of infection exhaled H2O2 (median, ranges) was 0.20 μM (0.03-1.2 μM), and this decreased to 0.09 μM (< 0.01-0.40 μM) after recovery (p=0.006). There was no significant difference in lung function (forced vital capacity and forced expiratory volume in 1 sec) during and after colds. In the controls, exhaled H2O2 did not change over a 2-week period.Conclusions: H2O2 in exhaled air condensate is elevated during a common cold, and returns to normal within 2 weeks of recovery in healthy subjects. Hence, symptomatic upper respiratory tract infection may act as a confounder in studies of H2O2 as a marker of chronic lower airway inflammation.

Copyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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